Method of treating gastrointestinal ulcers with spiro hydantoins

Details Method of treating gastrointestinal ulcers with spiro hydantoins Method of treating gastrointestinal ulcers with spiro hydantoins

1990-10-22

1992-10-13

Waddell, Frederick E.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514926, A01N 4350

Patent

active

051551250

ABSTRACT:
A therapeutic preparation for ulcers contains as a primary ingredient a compound having an aldose reductase inhibitory activity and can accelerate dermal metabolism. That compound may be d-6-fluoro-2,3-dihydro-2',5'-dioxo-spiro [4H-1-benzopyran-4,4'-imidazolidine]-2-carboxyamide, d-2-chloromethyl-6-fluoro-2,3-dihydro-spiro [4H-1-benzopyran-4,4'-imidazolidine]-2',5'-dione and d-2-bromomethyl-6-fluoro-2,3-dihydro-spiro [4H-1-benzopyran-4,4'-imidazolidine]-2',5'-dione.

REFERENCES:
patent: 4147795 (1979-04-01), Sarges
patent: 4248882 (1981-02-01), Sarges
Awata et al.,-Chem. Abst. 110(7) 51273 (Feb. 13, 1989) Abst. of Article in J. Ocul. Pharmacol 1988.

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