Drug – bio-affecting and body treating compositions – Enzyme or coenzyme containing – Hydrolases
Patent
1983-05-26
1985-12-31
Rosen, Sam
Drug, bio-affecting and body treating compositions
Enzyme or coenzyme containing
Hydrolases
A61K 3748
Patent
active
045620717
ABSTRACT:
A therapeutic agent for the treatment of diabetic nephropathy is disclosed which contains elastase as active ingredient.
REFERENCES:
Diabetes Mellitus, Seventh Edition, 1967, Eli Lilly and Company.
Davies, M. et al., Chemical Abstracts, 89: 3835z, "The Degradation of Human Glomerular Basement Membrane with Purified Lysosomal Proteinases. Evidence for the Pathogenic Role of the Polymorphonuclear Leukocyte in Glomerulonephritis", vol. 89 (1978).
Oikawa, Shinichi et al., Chemical Abstracts, 97: 192934e, "Inhibitory Effect of Pancreatic Elastase on Thickening of the Renal Glomerular Basement Membrane in the Spontaneously Diabetic Rat", vol. 97 (1982).
Shibata, Masao et al., Chemical Abstracts, 95: 59421c, "Inhibitory Effect of Elastase on the Glomerular Capillary Basement Membrane Thickening of the Experimental Congenital Diabetic Mice (N.S.Y. Mice)", vol. 95 (1981).
Hasegawa, Osamu, Chemical Abstracts, 94: 169968y, "Two New Methods for the Determination of Serum Elastase Activity and Their Clinical Significances", vol. 94 (1981).
Ramamurthy, N. S. et al., Chemical Abstracts, 99: 3739c, "Diabetes Increases Collagenase Activity in Extracts of Rat Gingiva and Skin", vol. 99 (1983).
Tamura, Shinji et al., Chemical Abstracts, 99: 173903u, "Studies on Elastase in Diabetic Rats", vol. 99 (1983).
Starkey, Phyllis M., Chemical Abstracts, 89: 125187k, "The Effect of Human Neutrophil Elastase and Cathepsin G on the Collagen of Cartilage, Tendon, and Cornea", vol. 89 (1978).
Davies, Malcom, et al., Chemical Abstracts, 94: 154025q, "The Binding of Human Lysosomal Elastase to Glomerular Basement Membrane", vol. 94 (1981).
Stuffers-Heiman, Marianne et al., Chemical Abstracts, 92: 108873a, "Immunological Properties of Glomerular Basement Membrane Antigens Solubilized by Elastase Digestion", vol. 92 (1980).
Matsutani et al.-Chem. Abst., vol. 98 (1983), p. 155,080y.
Oikawa et al.-Chem. Abst., vol. 92 (1980), p. 108570z.
Ikeda Tadasu
Mashiba Hiroto
Mokuda Osamu
Takeda Akira
Tokumori Yutaka
Eisai Co. Ltd.
Rosen Sam
LandOfFree
Method of treating diabetic nephropathy does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Method of treating diabetic nephropathy, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method of treating diabetic nephropathy will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1024083