Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,... – Reduced antigenicity – reduced ability to bind complement – or...
Patent
1983-07-25
1985-01-01
Robinson, Douglas W.
Drug, bio-affecting and body treating compositions
Immunoglobulin, antiserum, antibody, or antibody fragment,...
Reduced antigenicity, reduced ability to bind complement, or...
424300, 424309, A61K 3700, A61K 3127, A61K 3124
Patent
active
044915780
ABSTRACT:
This disclosure relates to a method of eliciting satiety (psycho phenomenetic sense of being filled) in mammals through the administration of an effective amount of a trypsin inhibitor and is based on the postulate that the enzyme trypsin, normally secreted by the pancreas, constitutes a negative feedback signal for cholecystokinin secretion which in turn comprises a putative satiety signal; thus, the effect of the trypsin inhibitor is to increase the concentration of cholecystokinin secretion advancing the sensation of satiety resulting in a consequent decrease in food intake and, over time, body weight.
REFERENCES:
patent: 4073884 (1978-02-01), Hartdegen et al.
Chem. Abst. 84, 133(e), (1976)-Okegawa et al.
Chem. Abst. 84, 218(m), (1976)-Aishita et al.
Chem. Abst. 99, 16995(h), (1983)-McLaughlin et al.
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