Prosthesis (i.e. – artificial body members) – parts thereof – or ai – Implantable prosthesis – Hair or skin
Patent
1994-04-19
1996-02-06
Green, Randall L.
Prosthesis (i.e., artificial body members), parts thereof, or ai
Implantable prosthesis
Hair or skin
623 11, 424422, 424426, A61F 210
Patent
active
054893046
ABSTRACT:
The present invention relates to a method of skin regeneration of a wound or burn in an animal or human. This method comprises the steps of initially covering the wound with a collagen glycosaminoglycan matrix, allowing infiltration of the grafted GC matrix by mesenchymal cells and blood vessels from healthy underlying tissue and applying a cultured epithelial autograft sheet grown from epidermal cells taken from the animal or human at a wound free site on the animal's or human's body surface. The resulting graft has excellent take rates and has the appearance, growth, maturation and differentiation of normal skin.
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T. Kangesu, et al., "A Porcine Model Using Skin Graft Chambers for Studied on Cultured Keratinocytes," British Journal of Plastic Surgery, 46:393-400 (1993).
N. Carver et al., "Restoration of Basement Membrane Structure in Pigs Following Keratinocyte Autografting," British Journal of Plastic Surgery, 46:384-392 (1993).
T. Kangesu, et al., "Kerato-dermal Grafts: The Importance of Dermis for the in vivo Growth of Cultured Keratinocytes," British Journal of Plastic Surgery, 46:401-409 (1993).
Bell et al., "Living Tissue Formed in vitro and Accepted as Skin-Equivalent Tissue of Full Thickness," Science, 211:1052-1054 (1981).
Barlow Mark
Butler Charles E.
Compton Carolyn C.
Orgill Dennis P.
Ritterbush Scott
Brigham & Women's Hospital
Clarke Rob
Green Randall L.
Integra LifeSciences Corporation
Massachusetts Institute of Technology
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