Method of selectively extracting osteogenic protein

Details Method of selectively extracting osteogenic protein Method of selectively extracting osteogenic protein

1995-05-23

1998-02-03

Loring, Susan A.

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

Separation or purification

530326, 530327, 530388, 530350, 5303879, 530395, 530840, 435 71, C07K 122, C07K 114, C07K 500, A61K 3702

Patent

active

057145890

ABSTRACT:
Disclosed are (1) osteogenic devices comprising a matrix containing substantially pure natural-sourced mammalian osteogenic protein; (2) DNA and amino acid sequences for novel polypeptide chains useful as subunits of dimeric osteogenic proteins; (3) vectors carrying sequences encoding these novel polypeptide chains and host cells transfected with these vectors; (4) methods of producing these polypeptide chains using recombinant DNA technology; (5) antibodies specific for these novel polypeptide chains; (6) osteogenic devices comprising these recombinantly produced proteins in association with an appropriate carrier matrix; and (7) methods of using the osteogenic devices to mimic the natural course of endochondral bone formation in mammals.

REFERENCES:
patent: 5266683 (1993-11-01), Oppermann et al.
patent: 5468845 (1995-11-01), Oppermann et al.

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