Method of selecting optimized SNP marker sets from multiple...

Details Method of selecting optimized SNP marker sets from multiple... Method of selecting optimized SNP marker sets from multiple...

2005-02-23

2009-12-01

Clow, Lori A (Department: 1631)

Data processing: measuring, calibrating, or testing

Measurement system in a specific environment

Biological or biochemical

Reexamination Certificate

active

07627436

ABSTRACT:
Provided is a method of selecting an optimized SNP marker set from a plurality of SNP markers. The method includes selecting an SNP marker set having a high association from a plurality of SNP markers using set-association, selecting SNP markers having a high association by performing discrimination analysis on arbitrary combinations of the markers included in the SNP marker set, and selecting an optimized SNP marker combination satisfying predetermined selection criteria by using receiver operating characteristics (ROC) curve analysis of arbitrary combinations of the selected SNP markers.

REFERENCES:
patent: 2003/0162207 (2003-08-01), Comings et al.
Comings et al. (2001) Clin. Genet. vol. 60, pp. 107-116.
“Trimming, Weighting, and Grouping SNPs in Human Case-Control Association Studies”, Cold Spring Harbor Laboratory Press ISSN 1088-9051/01, 11:2115-2119, Authors: Josephine Hoh, Anja Wille, and Jurg Ott Genome Research (2001)—citation annotated Jan. 1, 2008.
“Mathematical Multi-Locus Approaches to Localizing Complex Human Trait Genes”; Authors: Josephine Hoh and Jurg Ott.; Nature Reviews. Genetics.; pp. 701-709 (2003).
“Methods for Analysis and Visualization of SNP Genotype Data for Complex Dieases”; Authors: Anya Tsalenko, et al.; Pacific Symposium on Biocomputing; pp. 548-561 (2003).
“Trimming, Weighting, and Grouping SNPs in Human Case-Control Association Studies”; Authors: Josephine Hoh, et al.; Genome Research; pp. 2115-2119 (2001).
“Tissue Classification with Gene Expression Profiles”; Authors: Amir Ben-Dor, et al.; Journal of Computational Biology; vol. 7, No. 3/4, pp. 559-583 (2000).

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