Drug – bio-affecting and body treating compositions – In vivo diagnosis or in vivo testing
Patent
1996-09-20
2000-06-06
Duffy, Patricia A.
Drug, bio-affecting and body treating compositions
In vivo diagnosis or in vivo testing
424 92, 435 721, 435 78, 436 63, 436501, 436503, 436504, A61K 4900, G01N 33567, G01N 33566
Patent
active
06071493&
ABSTRACT:
The present invention is directed to screening for an agent that inhibits mononuclear phagocyte-plaque component complex formation (hereinafter "complex formation"). The methods include the steps of contacting a mononuclear phagocyte with a plaque component to stimulate complex formation and adding an agent suspected of inhibiting complex formation, measuring complex formation, and comparing complex formation to a measured control, wherein the reduction of complex formation compared to the control results in detection of an agent that inhibits complex formation. The mononuclear phagocytes may be from mammalian brain. The plaque component may be coupled to a solid support.
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Baylor College of Medicine
Corder Timothy S.
Duffy Patricia A.
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