Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1997-02-20
1999-08-03
Spivack, Phyllis G.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
A61K 31495
Patent
active
059325810
ABSTRACT:
A method of preventing tissue damage resulting from ischemia, comprising administering to a patient in need of such treatment an effective amount of a sorbitol dehydrogenase inhibitor.
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Joseph R. Williamson et al., "Perspective in Diabetes, Hyperglycemic Pseudohypoxia and Diabetic Complications", Diabetes vol. 42, 801-813, Jun. 1993.
Diabetes, vol. 44,--Feb. 1995, pp. 234-242, XP000654520 Tilton et al.: "Inhibition of Sorbitol Dehydrogenase: Effects of Vascular and Neural Dysfunction in Streptozocin-induced Diabetic Rats".
Diabetologia, vol. 40, No. 3, 1997, pp. 271-281, XP002032766 Cameron et al.: "Comparison of the Effects of Inhibitors of Aldose Reductase and Sorbitol Dehydrogenase on Neurovascular Function, Nerve Conduction and Tissue Polyol Pathway Metabolites in Streptozocin-diabetic Rats:".
Arzneimittel-Forschun/Drug Research, vol. 44, No. 9, 1994, Main, Germany, pp. 1032-1043, XP000652228 Geisen Karl et al.: "Sorbitol-Accumulating Pyrimidine Derivatives."
Beyer Thomas A.
Knight, Jr. Delvin R.
Mylari Banavara L.
Oates Peter J.
Pettipher E. Roy
Benson Gregg C.
Olson A. Dean
Pfizer Inc.
Richardson Peter C.
Spivack Phyllis G.
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