Method of producing prefilled sterile plastic syringes

Details Method of producing prefilled sterile plastic syringes Method of producing prefilled sterile plastic syringes

1986-12-08

1988-01-12

Bell, Jr., Houston S.

Fluent material handling, with receiver or receiver coacting mea

Processes

With material treatment

141 91, 141326, 134 221, 134169R, 422 25, B65B 304

Patent

active

047184639

ABSTRACT:
There is disclosed a process for producing sterilized prefilled plastic syringes avoiding plastic deformation and distortion. The plastic barrels are subjected to repeated water jet washing steps to remove contaminants and depyrogenate the barrels. Tip seals and pistons are subjected to removal of debris and pyrogens and destruction of microbial contaminants. After the tip is assembled on the nozzle of the barrel, the barrel is filled with contrast media through its open end, after which the piston is assembled in the open end to seal the syringe and its contents. The assembled and sealed syringe is then subjected to autoclaving to sterilize the syringe and its contents, without deformation of the plastic syringe or a loss of integrity to the closed media/syringe system.

REFERENCES:
patent: 3623474 (1971-11-01), Hellman et al.
patent: 3701345 (1972-10-01), Hellman et al.
patent: 4006736 (1977-02-01), Kranys et al.
patent: 4273263 (1981-06-01), Voegele et al.
Amsco Tech Data Sheet, Amsco--1980.

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