Method of preparing polymers having terminal amine groups

Details Method of preparing polymers having terminal amine groups Method of preparing polymers having terminal amine groups

2007-11-27

2007-11-27

Truong, Duc (Department: 1711)

Synthetic resins or natural rubbers -- part of the class 520 ser

Synthetic resins

From phosphorus-containing reactant

C528S004000, C528S397000, C528S422000, C528S425000, C528S480000, C528S487000, C528S488000

Reexamination Certificate

active

11212901

ABSTRACT:
The present invention is directed to methods of preparing linear polymers such as polyalkylene oxides containing a terminal amine in high purity. One preferred method includes reacting a polyalkylene oxide such as polyethylene glycol containing a terminal azide with a phosphine-based reducing agent such as triphenylphosphine or an alkali metal borohydride reducing agent such as sodium borohydride in a solvent to reflux. The resultant polymer-amines are of sufficient purity so that expensive and time consuming purification steps required for pharmaceutical grade polymers are avoided.

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