Method of preparing norbenzomorphane as an intermediate

Details Method of preparing norbenzomorphane as an intermediate Method of preparing norbenzomorphane as an intermediate

1999-02-24

2000-04-25

Shah, Mukund J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

560 37, C07C21127, C07C21918

Patent

active

060546042

ABSTRACT:
The present invention relates to new processes for preparing norbenzomorphan, the central intermediate step in the preparation of pharmaceutically useful benzomorphan derivatives of general formula 1 ##STR1## especially (-)-(1R,5S,2"R)-3'-hydroxy-2-(2-methoxypropyl)-5,9,9-trimethyl-6,7-benzomo rphan or [(-)-(2R,6S,2'R)-3-(2-methoxypropyl)-6,11,11-trimethyl-1,2,3,4,5,6-hexahyd ro-2,6-methano-benzo[.alpha.]oxacin-9-ol] (BIII 277).

REFERENCES:
patent: 5945535 (1999-08-01), Grauert et al.

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