Method of making iron(III)gluconate complex

Details Method of making iron(III)gluconate complex Method of making iron(III)gluconate complex

2006-02-28

2006-02-28

Nazario-Gonzalez, Porfirio (Department: 1621)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heavy metal containing

C556S147000, C514S502000, C536S113000

Reexamination Certificate

active

07005531

ABSTRACT:
The present invention refers to a method for making iron(III)gluconate complex, preferably alkali iron(III)gluconate complex. The method includes the following steps: (i) mixing a water soluble iron(III)salt in aqueous solution, simultaneously or in any desired sequence, with a member selected from gluconic acid, a water soluble salt of gluconic acid and combinations thereof, and a member selected from an alkali hydroxide, an alkali carbonate, an alkali hydrogen carbonate and combinations thereof, so that the reaction mixture has an acid value (pH-value) within the range of from 7.0 to 12, provided that when alkali hydroxide is used, gluconic acid or a water soluble salt of gluconic acid is provided at the beginning of the reaction or is added to the reaction mixture simultaneously with the alkali hydroxide; (ii) heating the reaction mixture until the iron(III)gluconate complex has formed; and (iii) adding an organic solvent which is miscible with water until the iron(III)gluconate complex is precipitated. The present invention also refers to pharmaceutical compositions including the iron(III)gluconate complex and methods of treating anemic conditions.

REFERENCES:
patent: 6693211 (2004-02-01), Kumari et al.
patent: 2003/0216566 (2003-11-01), Kumari et al.
patent: 2005/0209322 (2005-09-01), Rangisetty et al.
Folkert et al., American Journal of Kidney Diseases, vol. 41, No. 3, pp. 651-657 (Mar. 2003).

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