Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Ester doai
Patent
1991-11-15
1994-05-17
Goldberg, Jerome D.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Ester doai
A61K 31275
Patent
active
053128338
ABSTRACT:
Tumor growth in a mammal is inhibited by the administration of an effective amount of xanthocillin X dimethylether. The xanthocillin X dimethylether is administered in a range of 10-3,000 milligrams per day for an average adult human patient. The xanthocillin X dimethylether can be administered orally, by direct application into a neoplastic lesion, or by other parenteral forms of administration including intravenous, subcutaneous, or intramuscular injections. Also, suppository forms can be used.
REFERENCES:
C. Takahashi et al., "The Structures of Toxic Metabolites of Aspergillus candidus. II. The Compound B (Xanthoascin), a Hepato- and Cardio-toxic Xanthocillin Analog" in Chem. and Pharma. Bul., vol. 24, No. 10, Oct. 1976, pp. 2317-2321.
N. Kitahara et al., "Xanthocillin X Monomethylether, a Potent Inhibitor of Prostaglandin biosynthesis" in Jour. of Antibiotics, vol. 34, No. 12, Dec. 1981, pp. 1556-1561.
K. Ando et al., "A New Antibiotic, 1-(p-hydroxyphenyl)-2,3-diisocyano-4-(p-methoxyphenyl)-buta-1,3-diene. I. Isolation and Biological Properties", Jour. of Antibiotics, vol. 21, No. 10, Oct. 1986, pp. 582-586.
A. Takatsuki et al., "New Antiviral Antibiotics: Xanthocillin X mono and Dimethylether and Methoxyxanthocillin X Dimethylether . . . ", Jour. of Antibiotics, vol. 21, No. 12, Dec. 1968, pp. 676-680.
The Merck Index, 10th Ed, Merck & Co., Inc., Rahway, N.J., 1983, pp. 1444-1445 No. 9873.
Fukuyasu Harumi
Kawaharajo Katsumi
Koyama Masao
Kurihara Hiroshi
Tsuruoka Tsutomu
Goldberg Jerome D.
Meiji Seika Kaisha Ltd.
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