Method of identifying transmembrane protein-interacting...

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C435S007200, C435S007210, C436S501000

Reexamination Certificate

active

10509787

ABSTRACT:
A method for screening compounds for their ability to interact with transmembrane proteins is provided. Also provided is a method for determining whether proteins such as transmembrane proteins are able to oligomerize.

REFERENCES:
patent: WO 97/48820 (1997-12-01), None
patent: WO 99/05177 (1999-02-01), None
patent: WO 02/14475 (2002-02-01), None
Bailey et al.; “Patent Status of the therapeutically important G-protein-coupled receptors”,Expert Opin. Ther. Patents11: 1861-1887 (2001).
Barak et al.; “A β-Arrestin/Green Fluorescent Protein Biosensor for Detecting G Protein-coupled Receptor Activation”,The Journal of Biological Chemistry272: 44 27497-27500 (1997).
Bertin et al.; “Cellular signaling by an agonist-activated receptor/G5α fusion protein”,Proc. Natl. Acad. Sci. 91: 8827-8831 (1994).
Chen et al.; “A functional angiotensin II receptor-GFP fusion protein: evidence fro agonist-dependent nuclear translocation”,Am J Physical Renal Physiol279: F440-F448 (2000).
Conway et al.; “Quantitative analysis of Agonist-dependent parathyroid hormone receptor trafficking in whole cells using a functional green fluorescent protein conjugate”,J of Celular Phyisiol189: 341-355 (2001).
Coward et al.; “Chimeric G proteins allow a high-throughput signaling assay of Gi-Coupled receptors”Analytical Biochemistry270: 242-248 (1999).
George et al.; “Oligomerization of μ and δ-Opioid receptors”,J of Biological Chemistry275:34 26128-26135 (2000).
George et al.; “G-protein coupled receptor oligomerization and its potential for drug discovery”,Nature1: 808-820 (2002).
Görlich et al.; “Nucleocytoplasmic transport”,Science271: 1513-1518 (1996).
Grötzinger; “Molecular mechanisms of cytokine receptor activation”,Biochimica et Biophysica Acta1592: 215-223 (2002).
Hailey et al.; “Fluorescence resonance energy transfer using color variants of green fluorescent protein”,Methods in Enzymology351: 34-49 (2002).
Hanahan et al.; “Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis”,Cell86: 353-364 (1996).
Howard et al.; “Orphan G-protein-coupled receptors and natural ligand discovery”,Trends in Pharmacological Sciences22:3 132-140 (2001).
Howell et al.; “Live-cell nucleocytoplasmic protein shuttle assay utilizing laser confocal microscopy and FRAP”,BioTechniques32: 80-87 (2002).
Jans et al.; “Nuclear targeting signal recognition: a key control point in nuclear transport?”,BioEssays22: 532-544 (2000).
Lee et al.; “Novel G-protein-coupled receptor genes expressed in the brain: continued discovery of important therapeutic targets”,Expert Opin. Ther. Targets6: 2 185-202 (2002).
Lee et al.; “Oligomerization of dopamine and serotonin receptors”,Neuropsychopharmacology23: S32-S40 (2000).
Lu et al.; “Angiotensin II-Induced nuclear targeting of the Angiotenin Type 1 (AT1) receptor in brain neurons”,Endocrinology139:1 365-375 (1998).
Masson et al.; “Neurotransmitter transporters in the central nervous system”,Pharmacological Reviews51:3 439-464 (1999).
Matz et al.; “Fluorescent proteins from nonbioluminescent anthozoa species”,Nature Biotechnology17: 969-973 (1999).
Nakae et al.; “Distinct and overlapping functions of insulin and IGF-l receptors”,Endrocrine Reviews22: 6 818-835 (2001).
Nicholson et al.; “EGFR and cancer prognosis”,European Journal of Cancer37: S9-S15 (2001).
O'Dowd et al.; “Short Communication: Discovery of three novel G-protein-coupled receptor genes”,Genomics47: 310-313 (1997).
Prasher et al.; “Primary structure of the Aequorea Victoria green-fluorescent protein”,Gene111: 229-233 (1992).
Schlenstedt; “Protein import into the nucleus”,Fed. Of Europ. Biocehm. Soc. 389: 75-79 (1996).
Shawver et al.; “Smart drugs: tyrosine kinase inhibitors in cancer therapy”,Cancer Cell1: 117-123 (2002).
Smith; “Screening for drug discovery: the leading question”,Nature418: 452-459 (2002)
Strickland et al.; “Diverse roles for the LDL receptor family”,Trends in Endocrinology&Metabolism13: 2 (66-73).
Watson et al.; “Nuclear localization of the type 1 parathyroid hormone/parathyroid hormone-related peptide receptor in MC3T3-E1 cells: association with serum0induced cell proliferation”,Bone26:3 221-225 (2000).
Weis; “Importins and exportins: how to get in and out of the nucleus”,TIBS23: 185-189 (1998).
White et al.; “Heterodimerization is required for the formation of a functional GABABreceptor”Nature396: 679-682 (1998).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Method of identifying transmembrane protein-interacting... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Method of identifying transmembrane protein-interacting..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method of identifying transmembrane protein-interacting... will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3847467

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.