Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Reexamination Certificate
2005-02-08
2005-02-08
McKelvey, Terry (Department: 1636)
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
C435S320100, C435S325000
Reexamination Certificate
active
06852845
ABSTRACT:
The invention provides methods of identifying toxic agents, e.g., hepatotoxic agents, using differential gene expression. Also provided are methods of predicting the risk level and or injury type of NSAIDs. Also disclosed are novel nucleic acid sequences whose expression is differentially regulated by NSAIDs.
REFERENCES:
patent: 5871697 (1999-02-01), Rothberg et al.
patent: WO 9927090 (1999-06-01), None
patent: WO 9939200 (1999-08-01), None
patent: WO 0063435 (2000-10-01), None
Verma et al (1997) Nature 389:239-242.*
Palù (1999) J. Biotechnol. 68: 1-13.*
Luo et al (2000) Nature Biotechnology 18:33-37.*
Fox, ASM News, Feb. 2000, 66 (2): 1-3.*
Adams, et al., 2000 “The genome sequence of Drosophila melanogaster.”Science287:2185-2195. GenBank Accession No.: Q9VIA2.
Ayte, et al., 1990 “Rat mitochondrial and cytosolic 3-hydroxy-3-methylglutaryl-CoA synthases are encoded by two different genes.”Proc. Natl. Acad. Sci.U.S. A. 87, 3874-3878. GenBank Accession No.: M33648.
Cui, et al., 1983 Cloning and expression of a novel phosphatidylethanolamine N-methyltransferase. A specific biochemical and cytological marker for a unique membrane fraction in rat liver.J. Biol. CHem.268 (22), 16655-16663. GenBank Accession No.: L14441.
Donaldson, et al., 1993 “Expression of rat liver ketohexokinase in yeast results in fructose Intolerance.”Biochem. J.291, 179-186. GenBank Accession No.: M86235.
Dziuda, D. (1990). “Specialized PC software package for creation of computer systems supporting partial diagnostics based on numerical results of medical examinations.”Med Inform(Lond) 15(4): 319-26.
Furuta, et al., 1986 “Complete nucleotide sequence of cDNA and deduced amino acid sequence of rat liver catalase.”Proc. Natl. Acad. Sci. U.S.A.83, 313-317. GenBank Accession No.: M11670.
Heikkinen, S., 2000 “Mouse hexokinase II gene: structure, cDNA, promoter analysis, and expression pattern.”Mamm. Genome11 (2): 91-96. GenBank Accession No.: AJ238540.
Ishidoh, et al., 1991 “Molecular cloning of cDNA for rat cathepsin C. Cathepsin C. cysteine proteinase with an extremely long propeptide.”J. Biol. Chem.266 (25), 16312-16317. GenBank Accession No.: D90404.
Lacson, et al., 1994 “Dideoxy sequencing and structural analysis of the rat insulin-like growth factor binding protein-1 gene.”Biochim. Biophys. Acta1218 (1), 95-98. GenBank Accession No.: L22979.
Lafreniere, et al., 1996 “Isolation and characterization of GT335, a novel human gene conserved inEscherichia coliand mapping to 21q22.3.”Genomics38 (3): 264-272. GenBank Accession No.: U53003.
Lee, et al., 1998 “Rat Genome Project: Generation of a Rat EST (REST) Catalog & Rat Gene Index.” Direct Submission. GenBank Accession No.: AI169175.
Lee, et al., 1998 “Rat Genome Project: Generation of a Rat EST (REST) Catalog & Rat Gene Index.” Direct Submission. GenBank Accession No.: AA851963.
Matos P., 2000 “Small GTPase Rac1: Structure, Localization, and Expression of the Human Gene.”Biochem. Biohphys. Res. Commun.277 (3): 741-751. GenBank Accession No.: AJ132695.
Meier, E. 1990 Direct Submission. GenBank Accession No.: X52713.
Meier, E., 1990 “Activity of rat Mx proteins against a rhabdovirus.”J. Virol.64 (12): 6263-6269. GenBank Accession No.: P18590.
Nagamine, et al., “Isolation of cDNA for a novel human protein KNP-I that is homologous to theE. coliSCRP-27A protein from the autoimmune polyglandular disease type I (APECED) region of chromosome 21q22.3.”Biochem. Biophys. Res. Commun.225 (2), 608-616. GenBank Accession No.: P30042.
Ohtsuka K., 1999 “Mammalian HSP40/DNAJ homologs: Cloning of novel cDNAs and propoasl RT for the classification and nomenclature.” Direct Submision. GenBank Accession No.: Q9UBS4.
Shimkets, R. A., D. G. Lowe, et al. (1999). “Gene expression analysis by transcript profiliing coupled to a gene database query.”Nat. Biotechnol.17 (8): 798-803.
Soares, MB, 2000 Direct Submission. GenBank Accession No.: AW435096.
Sowden, et al. 1997 “Rat betaine-homocysteine methyltransferase (BHMT) mRNA.” Direct Submission. GenBank Accession No.: AF038870.
Watabe, et al., 1994 “Molecular cloning and functions of rat liver hydroxysteroid sulfotransferases catalysing covalent binding of carcinogenic polycyclic arylmethanois to DNA.”Chem. Biol. Interact.92 (1-3), 87-105, GenBank Accession No.: D14989.
Wilson R., 1994 “RT 2.2 Mb of contiguous nucleotide sequence from chromosome III of C.RT elegans.”Nature368:32-38. GenBank Accession No.: Q19527.
Zimmermann, R. 1999 Direct Submission. GenBank Accession No.: AJ250137.
Bhattacharjee, A. et al. (1998).Toxicology and Applied Pharmacology 150: 186-195.
Bonaldo, M. et al. (1996).Genome Research 6: 791-806.
International Search Report, Aug. 27, 2001.
DiPippo Vincent A.
Gerwein Robert W.
Ramesh Tenmore M.
Rothberg Bonnie Gould
Biswas, Esq. Naomi S.
Curagen Corporation
Elrifi, Esq. Ivor R.
McKelvey Terry
Mintz Levin Cohn Ferris Glovsky & Popeo P.C.
LandOfFree
Method of identifying toxic agents using NSAID-induced... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Method of identifying toxic agents using NSAID-induced..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method of identifying toxic agents using NSAID-induced... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3498635