Method of eliminating genetic routes for bacteriophage evolution

Details Method of eliminating genetic routes for bacteriophage evolution Method of eliminating genetic routes for bacteriophage evolution

1994-04-19

1996-12-03

Zitomer, Stephanie W.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

435 5, 4351723, 4352351, 4352523, 4352529, 935 55, 935 72, C12N 1563, C12Q 168, C12Q 170

Patent

active

055807259

ABSTRACT:
A process of identifying and disrupting bacterial DNA sequences that contribute to the evolution of new lytic bacteriophages is described. Vectors and recombinant bacteria for use in producing fermentative starter cultures and culture media resistant to the appearance of new phages, and methods of producing such vectors and recombinant bacteria, are described.

REFERENCES:
patent: 4530904 (1985-07-01), Hershberger et al.
patent: 4883756 (1989-11-01), Klaenhammer et al.
patent: 4931396 (1990-06-01), Klaenhammer et al.
patent: 5139950 (1992-08-01), Klaenhammer et al.
Durmaz et al. J. Bacteriology 174(22):7463-7469, 1992.
Sanders et al. Applied and Evironmental Microbiology 52(5):1001-1007, 1986.
Fitzgerald et al. J. Chem. Tech. and Biotech. 58:195-199, 1993.
O'Sullivan et al., Effect of Increasing the Copy Number of Bacteriophage Origins of Replication, in Trans, on Incoming-Phage Proliferation, Applied and Environmental Microbiology, vol. 59, No. 8, Aug. 1993, pp. 2449-2456.
Alatossava et al., Molecular Characterization of Three Small Isometric-Headed Bacteriophages Which Vary in Their Sensitivity to the Lactococcal Phage Resistance Plasmid pTR2030, Applied and Environmental Microbiology, vol. 57, No. 5, May 1991, pp. 1346-1353.
Todd R. Klaenhammer, Development of Bacteriophage-Resistant Strains of Lactic Acid Bacteria, Biochem. Soc. Trans., vol. 19, No. 3, Aug. 1991, pp. 675-681.
PCT International Search Report. (PCT/US95/04429).
R.K. Thunell et al., Phage-Insensitive, Multiple-Strain Approach to Cheddar Cheese Making.sup.a, J. Dairy Science 64, pp. 2270-2277. (1981).
T.R. Klaenhammer, Genetic Characterization of Multiple Mechanisms of Phage Defense from a Prototype Phage-Insensitive Strain, Lactococcus Iactis ME2.sup.1, J. Dairy Science 72, pp. 3429-3443 (1989).
Colin Hill, Bacteriophage and bacteriophage resistance in lactic acid bacteria, FEMS Microbiology Reviews 12 pp. 87-108 (1993).

Affiliated with

Also associated with

Rating

Method of eliminating genetic routes for bacteriophage evolution does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Method of eliminating genetic routes for bacteriophage evolution, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method of eliminating genetic routes for bacteriophage evolution will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-784460