Method for treating tumors with ethylenediamine platinum (II) an

Details Method for treating tumors with ethylenediamine platinum (II) an Method for treating tumors with ethylenediamine platinum (II) an

1979-12-26

1981-09-22

Goldberg, Jerome D.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Conjugate or complex

424204, 424287, A61K 31685, A61K 3166, A61K 3128

Patent

active

042910277

ABSTRACT:
Ethylenediamine platinum (II) and 1,2-diaminocyclohexane platinum (II) pyrophosphate complexes are prepared by reaction of the appropriate diaquo platinum (II) salt with a pyrophosphate salt. These complexes possess pronounced anti-tumor activity and low toxicity and thus have high therapeutic indices.

REFERENCES:
patent: 4115418 (1978-09-01), Gale et al.
patent: 4140707 (1979-02-01), Cleare et al.
Cleare, Platinum Coordination Complexes in Cancer Chemotherapy Springer-Verlag, N.Y., pp. 24-26, (1974).
Schwartz et al., Cancer Treatment Rep. 61, pp. 519-525, (1977).
Cleare et al., Bioinorganic Chemistry 2, pp. 196-200, (1973).
Leh et al., J. of Pharmaceutical Sciences, 65 (No. 3), pp. 319-320, (1976).

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