Method for treating thromboembolic conditions using thrombolytic

Details Method for treating thromboembolic conditions using thrombolytic Method for treating thromboembolic conditions using thrombolytic

1994-03-25

1997-10-14

Jacobson, Dian C.

Drug, bio-affecting and body treating compositions

Enzyme or coenzyme containing

Hydrolases

435212, 435226, 424 9464, A61K 3849, C12N 948, C12N 964

Patent

active

056769474

ABSTRACT:
The use of various thrombolytically active proteins in therapy is disclosed. The proteins are markedly superior to wild type t-PA in their pharmacokinetic, pharmacodynamic, and safety profiles.

REFERENCES:
Collen, D. et al., Blood 71:216-219 (1988).
Saito, et al. Ann. N.Y. Acad. Sci 613:452-454.
Suzuki, et al. Thromb. & Haemost. 62(1):393 (1989).
Fu, K.P. et al. Thrombosis Research 50:33-41 (1988).

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