Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1989-04-06
1993-04-13
Goldberg, Jerome D.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
514256, 514402, 514636, A61K 3155, A61K 31505, A61K 31415, A61K 31155
Patent
active
052023206
ABSTRACT:
This invention relates to a method for treating leishmaniasis which comprises administering to an afflicted host patient, a therapeutically effective amount of a compound having the following structure; ##STR1## wherein X is O or NH; R.sub.1 is H or two R.sub.1 of the same amidine group together represent --(CH.sub.2).sub.m -- wherein m=2, 3 or 4; R.sub.2 is H, NH.sub.2, OCH.sub.3, Cl or NO.sub.2 ; R.sub.3 is H, CH.sub.3 or CH.sub.2 CH.sub.3 and n=2-6 or a pharmaceutical acceptable salt thereof provided that X is O both R.sub.2 and both R.sub.3 cannot be H.
REFERENCES:
Reviews of Infectious Disease, vol. 10, No. 3 pp. 576-577.
Experimental Parasitology, vol 52, p. 404-413 (1981).
Geratz J. Dieter
Grogl Max
Hall James E.
Kyle Dennis E.
Ohemeng Kwasi A.
Drehkoff W. Dennis
Goldberg Jerome D.
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