Method for treating conditions mediated by PPAR using...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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Reexamination Certificate

active

07902254

ABSTRACT:
Disclosed is a method for treating PPAR (peroxisome proliferator activated receptor)-mediated diseases, such as diabetes mellitus, which includes administering to a subject an effective amount of macelignan represented by the following Formula (I):or a pharmaceutically acceptable salt thereof.

REFERENCES:
Shin et al (Arch. Pharm. Res., vol. 13, No. 3, pp. 265-268; 1990).
Ram, V.J. [“Therapeutic role of peroxisome proliferator-activated receptors in obesity, diabetes and inflammation.” in: Jucker, E., Progress in Drug Research (Switzerland, Birkhauser Verlag, Basel, 2003), pp. 93, 95 and 99-105].
Kreijkamp-Kaspers et al (Journal of Hypertension, vol. 22, No. 7, pp. 1381-1388; 2004).
Birrell et al (Eur Respir J, vol. 24, pp. 18-23; 2004).
Sérée et al. (Gastroenterology, vol. 127, No. 5, Abstract; 2004).
Roy et al. (Cancer Research, vol. 48, pp. 5726-5729; 1988).
Merck Manual reference (Retrieved on Feb. 26, 2010 from the Internet: <URL: http://www.merck.com/mmhe/sec11/ch144/ch144b.html?qt=glomerulonephritis&alt=sh).

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