Method for treating a migraine

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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514311, 514317, 514330, 514415, 514428, 514534, 514535, 514537, 514619, 514626, 514661, 514662, A61K 3144, A61K 3147, A61K 31445, A61K 31405

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active

059394250

ABSTRACT:
The migraine-treating effectiveness of a local anesthetic drug is significantly enhanced by coadministering dextromethorphan or dextrorphan.

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Skuza et al., "Memantine, Amantadine, and L-Deprenyl Potentiate the Action of L-DOPA in Monoamine-Depleted Rats", Journal of Neural Transmission, vol. 98, No. 1, 1994, pp. 57-67.
Rabey et al, "Selective Regional Effect of Various Neuroactive Drugs on Bromocriptine Concentration in the Brain of Rats", Acta Neurol. Scand., vol. 74, No. 4, 1986, pp. 289-292.
Hof et al, "Mutual Inhibition and Synergistic Effects of Ergotamine and the Calcium Antagonist Darodipine", Gen. Pharmacol., vol. 17, No., 3, 1986, pp. 309-314.
Bartoli, et al., "Does Lidocaine Affect Oxidative Dextromethorphan Metabolism In Vivo?" Giorn. Ital. Chim. Clin., vol. 18, No. 2, 1993, pp. 125-129.

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