Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1989-10-10
1990-08-07
Goldberg, Jerome D.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
A61K 3147
Patent
active
049468499
ABSTRACT:
A safe and effective therapeutic method for treating malaria. To accomplish treatment , anti-parasite agents are administered which consist of dequalinium salts. The salts are highly effective against chloroquine resistant/sensitive strains of human P. falciparum at low concentration levels.
REFERENCES:
Chemical Abstracts 107:223327r (1987).
Merck Index, 9th Ed., 1976 (compounds 2873-2874--p. 381).
Chemical Abstracts 109:167179w (1988).
Bleday, R. et al., Arch. Surg., 121:1272-1275 (1986).
Weiss, M. J. et al., Proc. Nat. Acad. Sci., 84:5444-5448 (1987).
Bodden et al., Biophy. Res. Comm., 135:574-582 (1986).
Scheibel, L., Proc. Nat. Acad. Sci., 84:7310-7314.
Bullough, D. A. et al., J. Biol. Chem., 264:9155-9163 (1989).
Choi, I. and Mugo, J. L., Mol. Biochem. Parasit., 31:71-78 (1988).
Rotenberg, S. A. et al., Proc.Annu. Meet. Am. Assoc. Cancer Res., 30:a25 (1989).
Trager, W. and Jensen, J., Science, 193:673-675 (1976).
Makler, M. T. et al., Cytometry, 8:568-570 (1987).
Wernsdorfer, W. H. et al., chapter 51, "Recent Progress of Malaria Research", Malaria, Principles and Practices of Malariology, vol. 2, Churchill Livingston Co., London (1988).
Bodden, W. L. et al., "Demonstration of Calmodulin (CAM Inhibition by Cytotoxic Antimitochondrial Agents (Meeting Abstract)", Proc. Annu. Meet. Am. Assoc. Cancer Res., 27:280 (1986).
Flow Incorporated
Goldberg Jerome D.
Malkin Jay K.
LandOfFree
Method for the treatment of malaria does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Method for the treatment of malaria, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method for the treatment of malaria will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-960832