Method for the treatment of cardiac failure with alkanoylimidazo

Details Method for the treatment of cardiac failure with alkanoylimidazo Method for the treatment of cardiac failure with alkanoylimidazo

1981-11-04

1983-01-04

Jiles, Henry R.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Parasitic organism or component thereof or substance...

424263, 548318, 548321, 546278, A61K 31415, A61K 3144

Patent

active

043672361

ABSTRACT:
4-Alkanoylimidazol-2-ones of the following general structure which are useful as cardiotonics in the treatment of cardiac failure ##STR1## wherein Q and T are each an oxygen atom or a divalent sulfur atom; R is hydrogen, lower alkyl, lower alkylcarbonyl or benzoyl; R.sub.1 is hydrogen or lower alkyl; R.sub.2 is a lower aliphatic hydrocarbon radical, phenyl alkylene or heterocyclo alkylene; and the pharmaceutically acceptable salts thereof.

REFERENCES:
patent: 2441933 (1948-05-01), Duschinsky
patent: 2441935 (1948-05-01), Duschinsky
patent: 2514380 (1950-07-01), Duschinsky
patent: 3303199 (1967-02-01), Doebel et al.
patent: 3361752 (1968-01-01), D'Amico
Duschinsky et al., J. Am. Chem. Soc., 1948, vol. 70, pp. 657-662.
Dage et al., Fed. Proc., 1980, vol. 39, p. 1105 (Abstract).
Kondo et al., J. Org. Chem., 1979, vol. 44 (24), pp. 4430-4435.
Duschinsky et al., J. Am. Chem. Soc., 1946, vol. 68, pp. 2350-2355.

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