Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Reexamination Certificate
2005-10-25
2005-10-25
Horlick, Kenneth R. (Department: 1637)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
C530S350000
Reexamination Certificate
active
06958218
ABSTRACT:
A method for the screening of ligands which bind to soluble α2δ-1 subtype polypeptides.
REFERENCES:
patent: 93/04083 (1993-03-01), None
patent: WO 95/04822 (1995-02-01), None
patent: 0020450 (2000-04-01), None
patent: WO 01/20336 (2001-03-01), None
Holland et al. A nonseparation microplate receptor binding Assay. Analytical Biochemistry, vol. 222, pp. 516-518.
Brown and Gee. Cloning and Deletion Mutagenesis of the Alpha 2 beta calcium channel subunit from porcine cerebral cortex. vol. 273, No. 39, pp. 25458-25465, Sep. 1998.
Gee, N.S., et al., The Journal of Biological Chemistry, The Novel Anticonvulsant Drug, Gabapentin (Neurontin), Binds to the Alpha2Delta Subunit of a Calcium Channel, 1996, vol. 271:10, pp. 5768-5776.
Brown, J.P., et al., The Journal of Biological Chemistry, “Cloning and Deletion Mutagenesis of the Alpha2Delta Calcium Channel Subunit from Porcine Cerebral Cortex”, 1998, vol. 273:39, pp. 25458-25465.
Kowalski, M.T., et al. Biochemical Society Transactions, “Effects of Anti-Calcium Channel A2-Subunit Antibodies on Calcium Flux and 1,4-Dihydropyridine Binding” 1990, p. 890.
Gurnett, C.A., et al., The J. of Biological Chemistry, “Extracellular Interaction of the Voltage-Dependent CA2+ Channel Alpha2 Delta and Alpha1 Subunits”, 1997, 272:29 PP 18508-18512.
Gurnett, C.A., et al., Neuron, “Dual Function of the Voltage-Dependent CA2+ Channel Alpha2Delta Subunit in Current Stimulation and Subunit Interaction” 1996, vol. 16, PP 431-440.
Felix, R., et al., J. of Neuroscience, “Dissection of Functional Domains of the Voltage-Dependent CA2+ Channel Alpha2Delta Subunit”, 1997, vol. 17:18, pp. 6884-6891.
Field, M.J., et al., British Journalof Pharmacology, “Gabapentin (Neurontin) and S-(+)-3-Isobutylgaba Represent a Novel Class of Selective Antihyperalgesic Agents”, 1997, vol. 121, pp. 1513-1522.
Klugbauer, N., et al., The Journal of Neuroscience, “Molecular Diversity of the Calcium Channel Alpha2Delta Subunit”, 1999, vol. 19:2, pp. 684-691.
Tokumaru, H., et al., European Journal of Pharmacology-Molecular Pharmacology Section, “Purification of the Cardiac 1,4-Dihydropyridine Receptor Using Immunoaffinity Chromatography with a Monoclonal Antibody Against the Alpha2Delta Subunit of the Skeletal Muscle Dihydropyridine Receptor” 1992, vol. 227, pp. 363-370.
Hill, D.R., et al., European Journal of Pharmacology-Molecular Pharmacology Section, “Localization of [3H]Gabapentin to a Novel Site in Rat Brain: Autoradiographic Studies”, 1993, vol. 244, pp. 303-309.
Dissanayake, V.U.K., et al., British Journal of Pharmacology, “Spermine Modulation FO Specific [3H]-Gabapentin Binding to the Detergent-Solubilized Porcine Cerebral Cortex Alpha2Delta Calcium Channel Subunit” 1997, vol. 120, pp. 833-840.
Brickley, K., et al., FEBS Letters, “Use of Site-Directed Antibodies to Probe the Topography of the Alpha2 Subunit of Voltage-Gated CA2+ Channels”, 1995, vol. 364, pp. 129-133.
Taylor, C.P., et al., Epilepsy Research, Potent and Stereospecific Anticonvulsant Activity of 3-Isobutyl Gaba Relates to in Vitro Binding at a Novel Site Labeled by Tritiated Gabapentin, 1993, vol. 14, pp. 11-15.
Thurlow, R.J., et al., European Journal of Pharmacology-Molecular Pharmacology Section, “[3H]Gabapentin May Label A System-L-Like Neutral Amino Acid Carrier in Brain”, 1993, vol. 247, pp. 341-345.
Suman-Chauhan, N., et al., European Journal of Pharmacology-Molecular Pharmacology Section, “Characterisation of [3H]Gabapentin Binding to a Novel Site in Rat Brain: Homogenate Binding Studies”, 1993, vol. 244, pp. 293-301.
Ellis, S.B., et al., Science, “Sequence and Expression of MRNAs Encoding the Alpha1 and Alpha2 Subunit of a DHP-Sensitive Calcium Channel”, 1988, vol. 241, pp. 1661-1664.
DeJongh, K.S., The Journal of Biological Chemistry, “Subunits of Purified Calcium Channels”, 1990, vol. 265, pp. 14738-14741.
Jay, S.D., et al., The Journal of Biological Chemistry, “Structural Characterization of the Dihydropyridine-Sensitive Calcium Channel Alpha2-Subunit and th eassociated Delta Peptides”, 1991, vol. 266, pp. 3287-3293.
Wiser, O., et al., FEBS Letters, The Alpha2/Delta Subunit of Voltage Sensitive CA2+ Channels is a Single Transmembrane Extracellular Protein Which is Involved in Regulated Secretion, 1996, vol. 379, pp. 15-20.
Brown, J.P., et al., Rev. Contemp. Pharmacother, “Mechanisms of Action of Gabapentin”, 1996, vol. 7, pp. 203-214.
Brown, J.P., et al., Analytical Biochemistry, “Isolation of the [3H]Gabapentin-Binding Protein/Alpha2Delta CA2+ Channel Subunit from Porcine Brain: Development of a Radioligand Binding Assay for Alpha2Delta Subunits Using [3H]Leucine”, 1998, vol. 255, pp. 236-243.
Holland et al., “A Nonseparation Microplate Receptor Binding Assay”,Analytical Biochemistry,vol. 222, 1994, pp. 516-518.
Bertelli François
Brown Jason Peter
Dissanayake Visaka Udeni Karalliadde
Gee Nicolas Steven
Suman-Chauhan Nirmala
Baude Eric J.
Ganjeizadeh Mehdi
Horlick Kenneth R.
King Karen B.
Warner-Lambert & Company
LandOfFree
Method for the screening of α2δ-1 subunit... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Method for the screening of α2δ-1 subunit..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method for the screening of α2δ-1 subunit... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3484277