Drug – bio-affecting and body treating compositions – Radionuclide or intended radionuclide containing; adjuvant...
Reexamination Certificate
2007-12-11
2007-12-11
Chan, Christina (Department: 1644)
Drug, bio-affecting and body treating compositions
Radionuclide or intended radionuclide containing; adjuvant...
C424S001530, C424S178100, C424S179100, C424S194100, C424S275100, C530S391100, C530S391500, C530S391900
Reexamination Certificate
active
10366569
ABSTRACT:
The present invention relates to a method for the preparation of a conjugate comprising a first and a second polypeptide, said method comprising the steps of (a) incubating said first polypeptide in the presence of a heterobifunctional crosslinker comprising an N-hydroxylsuccinimide ester group and a maleimide group linked via a polyethylene oxide spacer; (b) removing excess heterobifunctional crosslinker; and (c) incubating the reaction product of step (b) with said second polypeptide, wherein said second polypeptide comprises at least one sulfhydryl group. Furthermore, the present invention relates to a conjugate obtainable by the method of the present invention. Also described is a pharmaceutical composition comprising the conjugate of the present invention and, optionally, a pharmaceutically acceptable carrier and/or diluent, and the use of the conjugate for the preparation of a pharmaceutical composition for preventing and/or treating an allergic disease or an autoimmune disease.
REFERENCES:
patent: 4222907 (1980-09-01), Katz
patent: 5449669 (1995-09-01), Metcalfe et al.
patent: 40 14 540 (1991-11-01), None
patent: 0367 166 (1990-05-01), None
patent: WO89/11867 (1989-12-01), None
patent: WO91/08773 (1991-06-01), None
Borel et al, Int Arch Allergy Immunol 107(1-3): 264-7, May-Jun. 1995.
Fritsche et al, J Allergy Clin Immunol 93(4):778-86, Apr. 1994.
Burks et al, Eur J Biochem 245: 334-339, Feb. 1997.
Webster's II New Riverside University Dictionary, p. 933, 1984.
Voet, et al.Biochemisty I,1990, pp. 126-234.
Ngo, et al., 1994, “The Protein Folding Problem and Tertiary Structure Prediction,” pp. 492-495.
Fasier, et al.,J. Allergy and Clinical Immunology,101(4 pt 1): 521-30, Apr. 1998.
H.A. Sampson,J. Allergy and Clinical Immunol.78(1): 212-219 (1986).
R.E. Billingham, et al.,Nature172(4379):603-606 (1953).
J.W. Kappler, et al.,Cell49:273-280 (1987).
M.K. Jenkins and R.H. Schwartz,J. Exp. Med.165:302-319 (1987).
R.K. Gershon and K. Kondo,Immunology21:903-914 (1971).
M.A. Cremer, et al.,J. Immunol.131(6):2995-3000 (1983).
H.L. Weiner, et al.,Annu. Rev. Immunol.12:809-837 (1994).
W.Y. Lee and A.H. Sexhon,Nature267:618-619 (1977).
D.H. Katz, et al.,J. Exp. Med.134:201-223 (1971).
A. Muckerheide, et al.,J. Immunol.119(4):1340-1345 (1977).
J.J. Machiels, et al.,J. Clin. Invest.85:1024-1035 (1990).
Y. Borel, inTherapy of Autoimmune Diseases. Concepts in Immunopathology,(J.M. Cruse and R.E. Lewis, Jr., Eds.), 7:145-161, Karger, Basel (1989).
A.H. Sehon,Prog. Allergy32:161-202 (1982).
L.G. Fillion et al.,Cell Immunol.54:115-128 (1980).
H. Borel and Y. Borel,J. Immunological Methods126:159:168 (1990).
Y. Borel, et al.,J. Exp. Med.131:603-610 (1970).
Y. Borel, et al.,Annals New York Acad of Sci.778:80-87 (1996).
H. Tighe, et al., “Coupling of CpG Motif Immunostimulatory DNA to Ragweeg Allergen amba 1 Induces a Th1 Response to Allergen”Journal of Allergy and Clinical Immunology103(1):S48 (1999).
Monika Kroez, et al., “Therapy of Experimental Allergic Encephalomyelitis in Rats with Wubcutaneous Immunoglobulins”Journal of Autoimmunity(No. Suppl.):94 (1999).
L.S. Barak, et al. “Internal trafficking and surface mobility of a functionally intact beta2-adrenergic receptor-green fluorescent protein conjugate”Mol Pharmacol51(2): Abstract (1997).
X. Feng, et al., “Visualization of dynamic trafficking of a protein kinase C betaII/green fluorescent protein conjugate reveals differences in G protein-coupled receptor activiation and desensitization”J Biol Chem273(17): Abstract (1998).
D. Martinez-Fong, et al., “Neurotensin-SPDP-poly-L-lysine conjugate: a nonviral vector for targeted gene delivery to neural cells”Brain Res Mol Brain Res69(2): Abstract (1999).
E. Ishikawa, et al., “Potential of the immune complex transfer enzyme immunoassay for antigens and antibodies to improve the sensitivity and its limitations”J Clin Lab Anal12(3): Abstract (1998).
Borel Yves
Gelfand Erwin
Schlegel Werner
Chan Christina
Huynh Phuong
Pandiscio & Pandiscio
Tolerogen Ltd
LandOfFree
Method for the production of conjugates and uses thereof for... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Method for the production of conjugates and uses thereof for..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method for the production of conjugates and uses thereof for... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3849210