Combinatorial chemistry technology: method – library – apparatus – Method of screening a library – By measuring the effect on a living organism – tissue – or cell
Reexamination Certificate
2005-03-22
2010-12-07
Wessendorf, Teresa D. (Department: 1639)
Combinatorial chemistry technology: method, library, apparatus
Method of screening a library
By measuring the effect on a living organism, tissue, or cell
C435S390000, C435S383000, C435S373000, C506S007000
Reexamination Certificate
active
07846874
ABSTRACT:
The invention relates to the direct selection of metabolic pathways having a determined function in the transformation of a substrate {Ai} into a target product {B}, which is of interest in the industrial, pharmaceutical or agri-food sectors. More specifically, the invention relates to the detection, within metagenomic libraries, of novel biosynthesis pathways involved in a biochemical reaction having a known product {B}. The selection and characterization of said novel metabolic pathways enables {B} to be produced enzymatically. The invention provides an alternative to the chemical synthesis of the molecule in question {B}. Moreover, and above all, the invention can be used specifically to target and exploit the only metabolic pathways enabling the transformation of {Ai} into {B}, while eliminating the associated metabolic pathways that can catabolise the target product {B}.
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Rondon, M. R. et al. “Cloning the Soil Metagenome: A Strategy for Accessing the Genetic and Functional Diversity of Uncultured Microorganism”,Applied and Environmental Microbiology, Jun. 2000, pp. 2541-2547, vol. 66, No. 6.
Bensoussan Claude
Gillet Benjamin
Monsan Pierre
Nalin Renaud
Pujic Pierre
Libragen
Saliwanchik Lloyd & Saliwanchik
Wessendorf Teresa D.
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