Method for separating and purifying polyene macrolide antibiotic

Details Method for separating and purifying polyene macrolide antibiotic Method for separating and purifying polyene macrolide antibiotic

1990-02-02

1993-05-11

Rotman, Alan L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

210656, C07D31300

Patent

active

052102262

ABSTRACT:
The present invention provides for the first time an expeditious method to separate polyene macrolide antibiotics into their major components, through a general preparatory procedure employing high pressure liquid chromatography. The procedure allows for the first time a useable preparatory method for separating the polyene macrolide complexes derived from fermentation and cultivation of various organisms, into their major components. Substantially pure dermostatic A and dermostatic B can now be achieved as well as substantially pure mycoticin A and mycoticin B.

REFERENCES:
patent: 4707470 (1987-11-01), Kirsh et al.
patent: 4831018 (1989-05-01), Kirsh et al.
Wasserman et al "Biosynthesis of the mycoticins, metabolites of Streptomyces Ruber." CA 75 31631j (1971).
Merck Index #2880 (1983).

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