Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Reexamination Certificate
2004-10-07
2008-12-16
Landsman, Robert (Department: 1647)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
C435S007200
Reexamination Certificate
active
07465550
ABSTRACT:
The invention provides nucleic acid and amino acid sequences for a novel family of taste transduction G-protein coupled receptors, antibodies to such receptors, methods of detecting such nucleic acids and receptors, and methods of screening for modulators of taste transduction G-protein coupled receptors.
REFERENCES:
patent: WO 93/016178 (1993-08-01), None
patent: WO 98/13478 (1998-04-01), None
patent: WO 99/42470 (1999-08-01), None
patent: WO 00/38536 (2000-07-01), None
Wamsley, et al. “Human BAC clone GS1-113H23 from 5p15.2, complete sequence”EMBL Database Entry AC003015, Accession No. AC003015,Oct. 31, 1997, XP-002161964.
Adams, et al. “Use of a random human BAC End Sequence Database for Sequence-Ready Map Building; CITBI-E1-2530B8.TF CITBI-E1Homo sapiensgenomic clone 2530B8, genomic survey sequence”EMBL Database Entry AQ308694; Accession No. AQ308694,Dec. 23, 1998, XP-002161965.
Adler, et al. “ A Novel Family Mammalian Taste Receptors”Cellvol. 100, pp. 693-702 (2000), XP-000982304.
Chandrashekar, et al. “T2Rs Function as Bitter Taste Receptors”Cellvol. 100, pp. 703-711 (2000), XP-000982305.
Hoon, et al., “Putative Mammalian Taste Receptors: A Class of Taste-Specific GPCRs with Distinct Topographic Selectivity”; Cell, vol. 96, No. 4, pp. 541-551 (1999), XP-000960553.
Sambrook J., et al. “Molecular Cloning:A Laboratory Manual.” Second Ed. Cold Spring Harbor Laboratory Press, pp. 17.3-17.44, (1989).
Ogura T., et al.,J. Neurosci.,17(10), pp. 3580-3587, (1997).
Herrada and Dulac, “A Novel Family of Putative Pheromone Receptors in Mammals with a Topographically Organized and Sexually Dimorphic Distribution,”Cell90:763-773 (Aug. 22, 1997).
Matsunami and Buck, “A Multigene Family Encoding a Diverse Array of Putative Pheromone Receptors in Mammals,”Cell90:775-784 (Aug. 22, 1997).
Striem et al., “Sweet tastants stimulate adenylate cyclase coupled to GTP-binding protein in rat tongue membranes,”Biochem260:121-126 (1989).
Ryba and Tirindelli, “A New Multigene Family of Putative Pheromone Receptors,”Neuron19:371-379 (Aug. 1997).
Naito et al., “Putative pheromone receptors Ca2+—sensing receptor in . . . ,”Fugu Proc. Natl. Acad. Sci.95:5178-5181 (Apr. 1998).
Ian E. Lush, “The genetics of tasting mice,”Genet. Res. Camb.53:95-99 (1989).
Kinnamon and Margolskee, “Mechanisms of taste transduction,”Current Opinion in Neuriobiology6:506-513 (1996).
Hoon et al., “Putative Mammalian Taste Receptors: A Class of Taste-Specific GPCRs with Distinct Topographic Selectivity,”Cell96:541-551 (Feb. 19, 1999).
Hoon and Ryba, “Analysis and Comparison of Partial Sequences of Clones from a Taste—bud enriched cDNA Library,”J. Dent Res.76:831-838 (Apr. 1997).
Dulac and Axel, “A Novel Family of Genes Encoding Putative Pheromone Receptors in Mammals,”Cell83:195-206 (Oct. 20, 1995).
Chaudhari et al., “The Taste of Monosodium Glutamate: Membrane Receptors in Taste Buds,”Journal of Neuroscience16(12):3817-3826 (Jun. 15, 1996).
Cao et al., “Cloning and localization of two multigene receptor families in goldfish olfactory epithelium,”Proc. Natl. Acad. Sci.95:11987-11992 (Sep. 1998).
Wong et al., “Transduction of bitter and sweet taste by gustducin,”Letters to Nature381:796-800 (Jun. 27, 1996).
McLaughlin et al., “Gustducin is a taste-cell-specific G protein closely related to the transducins,”Letters to Nature357:563-569 (Jun. 18, 1992).
Brown et al., “Cloning and characterization of an extracellular Ca2+—sensing receptor from bovine parathyroid,”Letters to Nature366:575-580 (Dec. 9, 1993).
Kim et al., “Positional Cloning of the Human Quantitative Trait Locus Underlying Taste Sensitivity to Phenylthiocarbamide”,Science,2003, pp. 1221-1225, vol. 299.
Hillier et al., “The DNA sequence of human chromosome 7”,Nature, 2003, pp. 157-164, vol. 424.
Ming, D., et al., “Characterization and solubilization of bitter-responsive receptors that couple to gustducin,” Proc Nat'l Acad Sci USA, 95 (1998) p. 8933-8938.
Ming, D., et al., “Blocking taste receptor activation of gustducin inhibits gustatory responses to bitter compounds,” Proc Nat'l Acad Sci USA, 96 (1999)p. 9903-9908.
Höfer, D., et al., “Taste receptor-like cells in the rat gut identified by expression of α-gustducin,” Proc Nat'l Acad Sci USA, 93 (1996) p. 6631-6634.
Journal of Cookery Science of Japan, 30[2] (1997) p. 68-73.
Adams, Mark D., et al., “Sequence identification of 2,375 human brain genes,” Nature, pp. 632-634, vol. 355 (Feb. 13, 1992).
Munzy, D., et al., Database GenEmbl; Accession No. AC006518 (May 1, 1999).
Adler Jon Elliot
Hoon Mark
Mueller Ken
Ryba Nicholas J.P.
Zuker Charles S.
Landsman Robert
The Regents of the University of California
The United States of America as represented by the Department of
Townsend and Townsend / and Crew LLP
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