Method for quantifying lipopolysaccharide binding protein

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...

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435 75, 435 792, 435 795, 436501, 436811, G01N 33566, G01N 33569, C12Q 100

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active

054847052

ABSTRACT:
The present invention provides a method for quantifying the presence of extracellular LBP in body fluids including blood in a subject comprising conducting an LBP immunoassay on plasma obtained from said subject.

REFERENCES:
patent: 5245013 (1993-09-01), Ulevitch et al.
Dofferhoff, et al., "Tumor necrosis factor (cachectin) and other cykotines in septic shock: a review of the literature," Netherlands Journal of Medicine, 39:45-62 (1991).
Elsbach et al., "Separation and Purification of a Potent Bactericidal/Permeability-Increasing Protein and a Closely Associated Phospholipase A.sub.2 from Rabbit Polymorphonuclear Leukocytes," J. Biol. Chem.,254:11000-11009 (1979).
Erwin, et al., "Plasma Lippopolysaccharide-Deacylating Activity (Acyloxyacl Hydrolase) Increase After Lippopolysaccharide Administration to Rabbits," Laboratory Investigation, 65(2):138-144 (1991).
Gallay, et al., "Purification and Characterization of Murine Lipopolysaccharide-Binding Protein," Infection and Immunity, 61(2):378-383, (Feb., 1993).
Gazzano-Santoro et al., "High-Affinity Binding of the Bactericidal/Permeability-Increasing Protein and a Recombinant Amino-Terminal Fragment to the Lipid A Region of Lipopolysaccharide," Infection and Immunity, 60(11):4754-4761 (1992).
Geller, et al., "Induction of Hepatocyte Lipopolysaccharide Binding Protein in Models of Sepsis and the Acute-Phase Response," Arch. Surg. 128:22-28, (Jan., 1993).
Leturcq et al., "Generation of Monoclonal Antibodies to Human LBP and their Use in the Detection of LBP Protein in Serum," J. Cell. Biochem., 16C:161 (1992).
Marra, et al., "The Role of Bactericidal/Permeability-Increasing Protein as a Natural Inhibitor of Bacterial Endotoxin," J. Immunol., 148(2):532-537 (Jan. 15, 1992).
Pereira et al., "Quantitation of a Cationic Antimicrobial Granule Protein of Human Polymorphonuclear Leukocytes by ELISA," J. Immunol. Methods, 117:115-120 (1989).
Pesce et al., "Cationic Antigens--Problems Associated with Measurement by ELISA," J. Immunol. Methods, 87:21-27 (1986).
Schindler, et al., "Plasma levels of bactericidal/permeability-increasing protein (BPI) and lippopolysaccharide-binding protein (LBP) during hemodialysis," Clinical Nephrology, 40(6):346-351 (1993).
Schumann, et al., "Structure and Function of Lippopolysaccharide Binding Protein," Science, 249:1429-1433 (Sep. 21, 1990).
Spitznagel, et al., "Antibiotic Proteins of Human Neutrophils," J. Clin. Invest., 86:1381-1386 (1990).
Taber, et al., "Taber's Cyclopedic Medical Dictionary," Philadelphia: F. A. Davis Company, p. 545 (1985).
von der Mohien, et al., "Bactericidal Permeability Increasing Protein Levels Predict Survival in Patients with Gram-Negative Sepsis," Abstract presented at 13th International Symposium on Intensive Care and Emergency Medicine, (Brussels, Belgium) (1993).
Weiss, et al., "Cellular and Subcellular Localization of the Bactericidal/Permeability-Increasing Protein of Neutrophils," Blood, 69(2):652-659 (1987).
Weiss, et al., "Human Bactericidal/Permeability-Increasing Protein and a Recombinant NH.sub.2 -Terminal Fragment Cause Killing of Serum-Resistant Gram-Negative Bacteria in Whole Blood and Inhibit Tumor Necrosis Factor Release Induced by the Bacteria," J. Clin. Invest., 90:1122-1130 (Sep., 1992).
Weiss, et al., "Purification and Characterization of a Potent Bactericidal and Membrane Active Protein from the Granules of Human Polymorphonuclear Leukocytes," J. Biol. Chem., 253(8):2664-2672 (1978).
Wright, et al., "CD14, a Receptor for Complexes of Lipopolysaccharide (LPS) and LPS Binding Protein," Science, 249:1431-1433 (Sep. 21, 1990).
Ulevitch, Presentation at the American Society of Microbiology General Meeting in Atlanta, Ga. (May 16-21, 1993) (Session 13 Abstract 564).
Tobias et al., "Lipopolysaccharide Binding Protein", J. Cell. Biochem., 16 C:151 (Abstract (CB006) (1992).
Ballou et al., "Laboratory Evaluation of Inflammation," Textbook of Rheumatolgy, vol. 1, Ch. 40, pp. 671-679 (1993).
Baumann et al., "The acute phase response," Immunology Today, vol. 15, No. 2, pp. 74-80 (1994).
Grube et al., "Lipopolysaccharide Binding Protein Expression in Primary Human Hepatocytes and HepG2 Hepatoma Cells*," J. Biol. Chem., vol. 269, No. 11, pp. 8477-8482 (1994).
Raynes, "Carbohydrate Binding Proteins and Immune Responses," Biochemical Immunology Group/Glycobiology Group Joint Colloquium Organized by G. B. Wisdom and M. I. Halliday (The Queen's University, Belfast) and Edited by G. B. Wisdom. 648th Meeting held at The Queen's University, Belfast, 14-17 Sep. 1993, Biochemical Society Transactions, vol. 22, pp. 69-74 (1994).

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