Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Patent
1990-02-02
1992-10-27
Raymond, Richard L.
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
C07D31300
Patent
active
051590026
ABSTRACT:
The present invention provides a method for treating patients suffering from the acquired immunedeficiency syndrome (AIDS). The method comprises administering dermostatin, dermostatin A, dermostatin B or derivatives thereof, such as pharmaceutically acceptable esters, salts or complexes. The administration of the dermostatin or dermostatin A or dermostatin B should be done as soon as possible after the detection of the presence of the HIV virus which is believed to be responsible for the onset of AIDS. These polyene macrolide antibiotics have been found to be effective in improving the viability of lumphocyte cells infected with the HIV virus and in preventing the replication of the virus. The present invention also provides for the first time substantially pure dermostatin A and dermostatin B and an HPLC method for separation of dermostatin complex into those components in substantial purity.
REFERENCES:
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patent: 4863955 (1989-09-01), Moore et al.
R. Pandey et al., The Journal of Antibiotics, "Polyene Antibiotics," vol. XXVI, No. 8 pp. 475-477 (1973).
R. Pandey, Hindustan Antibiotics Bulletin, "The Structures of Dermostatin A and B," 22 (3 & 4), pp. 47-61 (1980).
H. Willard et al., "Instrumental Methods of Analysis" 6th ed., pp. 529-530 and 536-543, D. Van Nostrand Co. New York (1981).
N. Narasimhachari et al., Chemical Abstracts 65:5301c, "Purification of dermostatin . . . " (1965).
M. Windholz et al., "The Merck Index" 10th ed. entry 2280, p. 420, Merck & Co., Rahway, N.J. (1983).
R. Pandey et al., Chemical Abstracts 79:146360v, "Polyene Antibiotics," p. 311 (1973).
Drehkoff W. Dennis
Raymond Richard L.
Russell Mark W.
Xechem Inc.
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