Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Reexamination Certificate
2007-09-11
2010-02-23
Desai, Anand U (Department: 1656)
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
C435S226000, C435S252300, C435S254200, C435S254230, C435S320100, C536S023400
Reexamination Certificate
active
07666629
ABSTRACT:
The present invention concerns a method for producing recombinant trypsin from porcine pancreas inPichia pastoriswhich is soluble and secreted into the culture medium, whereby expression at pH 3.0-4.0 substantially prevents activation of trypsinogen to β-trypsin and autolysis of β-trypsin by α-trypsin into ε-trypsin and from there into inactive peptides.
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Eckstein Hellmut
Geipel Frank
Giessel Claudia
Glaser Stephan
Muller Rainer
Barnes & Thornburg LLP
Desai Anand U
Moore William W
Roche Diagnostics Operations Inc.
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