Organic compounds -- part of the class 532-570 series – Organic compounds – Carboxylic acid esters
Reexamination Certificate
2006-03-14
2006-03-14
Wilson, James O. (Department: 1624)
Organic compounds -- part of the class 532-570 series
Organic compounds
Carboxylic acid esters
C562S561000
Reexamination Certificate
active
07012152
ABSTRACT:
The present invention provides a method for industrially producing an optically active lysine derivative useful as a pharmaceutical intermediate. More particularly, the present invention provides a production method including protecting an amino group or an amino group and carboxyl group of optically active 2-amino-6-methyl-6-nitroheptanoic acid with a protecting group, reducing a nitro group to synthesize a 6,6-dimethyl lysine derivative and reacting the 6,6-dimethyl lysine derivative with an acetic acid derivative.
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S. Nagarjan, et al., J. Org. Chem., vol. 51, No. 25, pps. 4856-4861, “Chemistry of Naturally Occurring Polyamines. 10.1Nonmetabolizable Derivatives Of Spermine And Spermidine”, 1986.
J.A. Robl, et al., Journal of Medicinal Chemistry, vol. 42, No. 2, pps. 305-311, “Vasopeptidase Inhibitors: Incorporation of Geminal and Spirocyclic Substituted Azepinones in Mercaptoacyl Dipeptides”, 1999.
Izawa Kunisuke
Naito Masaki
Nakazawa Masakazu
Onishi Norimasa
Takahashi Daisuke
Ajinomoto Co. Inc.
Tucker Zachary C.
Wilson James O.
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