Method for producing a 3,5-dihydroxy-6-heptenoate

Details Method for producing a 3,5-dihydroxy-6-heptenoate Method for producing a 3,5-dihydroxy-6-heptenoate

2008-03-04

2008-03-04

Seaman, D. Margaret (Department: 1625)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C546S153000, C546S174000

Reexamination Certificate

active

07339062

ABSTRACT:
A method for producing an alkyl (3R,5S)-7-[2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl]-3,5-dihydroxy-6-heptenoate of the formula (1) (wherein R is a C1-4alkyl group), which is an intermediate for a cholesterol-reducing agent (a HMG-CoA reductase inhibitor), etc. A solution containing a compound of the formula (1) is subjected to liquid chromatography treatment using silica gel as the packing material, to separate its epimers contained therein.

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