Method for preparing (s)-indoline-2-carboxylic acid and...

Details Method for preparing (s)-indoline-2-carboxylic acid and... Method for preparing (s)-indoline-2-carboxylic acid and...

2004-11-03

2008-07-29

Lilling, Herbert J (Department: 1657)

Chemistry: molecular biology and microbiology

Process of utilizing an enzyme or micro-organism to destroy...

Resolution of optical isomers or purification of organic...

C435S121000, C435S195000, C435S196000, C435S197000

Reexamination Certificate

active

07405070

ABSTRACT:
Disclosed is a method for preparing (S)-indoline-2-carboxylic acid and (S)-indoline-2-carboxylic acid methyl ester using an inexpensive industrially available enzyme capable of assuring superior optical purity and yield. At this time, the hydrolytic enzyme is selected from the group consisting of Savinase, Alcalase, Novozym 243, Everlase, Esperase, Protease 7 and Acylase, whereby (S)-indoline-2-carboxylic acid and methyl ester thereof having an optical purity of at least 99% e.e. can be obtained through a simplified preparation process, thus generating economic benefits.

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