Non-nucleoside reverse transcriptase inhibitors

Details Non-nucleoside reverse transcriptase inhibitors Non-nucleoside reverse transcriptase inhibitors

2005-03-02

2008-07-29

Rao, Deepak (Department: 1624)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C549S466000

Reexamination Certificate

active

07405310

ABSTRACT:
This invention relates to non-nucleoside reverse transcriptase inhibitors active against HIV-1 and having an improved resistance and pharmacokinetic profile. The invention further relates to novel intermediates in the synthesis of such compounds and the use of the compounds in antiviral methods and compositions.

REFERENCES:
patent: 3803175 (1974-04-01), Sparks et al.
patent: 2041563 (1971-03-01), None
patent: WO 93/03022 (1993-02-01), None
patent: WO 95/06034 (1995-03-01), None
patent: WO 99/36406 (1999-07-01), None
patent: WO 99/47501 (1999-09-01), None
patent: WO 00/39095 (2000-07-01), None
patent: WO 00/47561 (2000-08-01), None
patent: WO 00/56736 (2000-09-01), None
patent: WO 00/78315 (2000-12-01), None
patent: WO 00/78721 (2000-12-01), None
patent: WO 00/78755 (2000-12-01), None
patent: WO 00/78756 (2000-12-01), None
Davidson et al., Use of 1,2,3-trisubstituted cyclopropanes as conformationally constrained peptide mimics in SH2 antagonists, Tetrahedron Letters, 41(49), pp. 9459-9464, 2000.
Derrick L.J. Clive et al., “Synthesis of (±) -puraquinonic acid: an inducer of cell . . . ,” J. Org. Chem. 2001, 66, pp. 954-961. XP-002216804.
M.G. Kulkarni et al., “Synthesis of novel 3-allylbenzofurans via . . . ,” Synthesis. 1997, 12, pp. 1420-1424. XP-001106509.
Biswajit Saha et al., “Intramolecular asymmetric cyclopropanation . . . ,” SYNLETT. 2001, 1(1), pp. 114-116. XP-001106507.
Chi-Ming Che et al., “Asymmetric inter- and intramolecular cyclopropanation . . . ,” J. Am. Chem. Soc. 2001, 123, pp. 4119-4129. XP-002216805.
Masakatsu Matsumoto et al., “o-Benzochinon-monoformylmethide durch . . . ,” Angew. Chem. 1982, 94(5), pp. 376-377. XP002216806.
Andre Rosowsky et al., “2,4-Diaminothiene [2,3-d]pyrimidine analogue . . . ,” J. Med. Chem. 1993, 36, pp. 3103-3112. XP-001106506.
Manik S. Sardessai et al., “The bromination of 2,5-dimethoyxbenzaldehyde . . . ,” Organic Preparations and Procedures Int. 1991, 23(4), pp. 419-424. XP-002216807.
Takao Sakamoto et al., “Condensed heteroaromatic ring systems . . . ,” Tetrahedron, 1991, 47 (10), pp. 1877-1886. XP001106510.
Stephen F. Martin et al., “Iodocyclopropanes as Versatile Intermediates . . . ,” Tetrahedron Letters, 1998, 39, pp. 1521-1524. XP002216808.
Tatsuya Uchida et al., “Co (II) -salen-catalyzed asymmetric intramolecular cyclopropanation . . . ,” Tetrahedron Letters, 2001, 42, pp. 2521-2524. XP-002216809.
Yuki Takekawa et al., “Selective cleavage of the trisubstituted . . . ,” Tetrahedron Letters, 1999, 40, pp. 6817-6820. XP-002216810.
Eric L. Dias et al., “Rhodium(I)—Catalyzed homologation of aromatic . . . ,” J. Am. Chem. Soc. 2001, 123. pp. 2442-2443. XP-002216811.
Robert S. Coleman et al., “A covergent approach to the . . . ,” Oraganic Letter, 2001, 3(8), pp. 1141-1144. XP-002216812.
Leticia Perez-Serrano et al., “Synthesis of tricyclic aromatic compounds by the . . . ,” J. Org. Chem. 2000, 65, pp. 3513-3519. XP-002216813.
Gregory H. Merriman et al., “The Synthesis of N- (Pyridylamino) tetrahydroisoquinolines and . . . ,” SYNLETT, 2000, 1, pp. 137-0139. XP001106583.
Arun K. Jain et al., “Some new constituents from . . . ,” J. Indian Chem. Soc., Aug. 1991, pp. 452-454. XP-002216814.
Reckendorf, W. Meyer eta l.; “Synthesis of Methyl 4, 6-O-Benzylidene-2, 3- . . . ” Angew. Chem. Internat. Edit. vol. 7 (1968) No. 2.
Reckendorf, W. Meyer et al.; “Synthese von 2.3-[2-Amino-athyliden]. . . ” Chem. Ber. 105, 686-695 (1972).
Hogberg, Marita et al.; “Urea-PETT Compounds as a New Class . . . ” J. Med. Chem. 1999, 42, 4150-4160.
Cantrell, Amanda S. et al.; “Phenethylthiazolythiourea (PETT) Coumpounds . . . ” J. Med. Chem. 199, 39, 4261-4274.
Bell, Frank W. et al.; “Phenethylthiazolethiourea (PETT) Compounds, a New Class of . . . ” Reprinted from Journal of Medicinal Chemistry, 1995, 38, pp. 4929-4936.
Kirmase, Wolgang et al.; “Carbenes and the O-H Bond: . . ” J. Org. Chem. 1988, 53, 763-767.
Badger et al., CAOLD Abstract 52:17228c, 1959.
Chatterjee et al., CAOLD 79:66064, 1973.
Chatterjee et al., Mechanism, Stereoselectivity and Generality of a Novel Cycloprpane Formation Letters, No. 19, pp. 1683-1686, 1973.

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