Method for preparing high potency sucralfate

Details Method for preparing high potency sucralfate Method for preparing high potency sucralfate

1988-12-16

1991-02-05

Brown, Johnnie R.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

C07H 1100, C07H 1312, A61K 31715

Patent

active

049906100

ABSTRACT:
Sucralfate is prepared in good yields and in newly useful form first by reacting sucrose with chlorosulfonic acid in 2-picoline. The amonium salt is then formed and reacted with aluminum chlorohydrate in specific sequence and alcoholic solvent. The two distinct products have unexpected pharmaceutical and physical characteristics. The oral liquid suspensions also must be critically formulated.

REFERENCES:
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patent: 3720659 (1973-03-01), Guiseley et al.
K. Ochi et al. Chem. Pharm. Bull 28(2) 638-641 (1980).
Nagashima et al. Arzneim Forsch 29: 1668 (1979).
The Merck Index, Tenth Edition No. 8755.
Chemical Abstracts No. 97: 198513p Maruko Pharmaceutical Co. Jpn. Kokai 82/67,595.
Chemical Abstracts vol. 104, Abstract No. 110116r, Montoro et al. Span. ES 519,512.
Chemical Abstracts Vol. 95, Abstract No. 187600x Maruko Pharmaceutical Jpn. Kokai 81/77,294.

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