Method for predicting pregnancy-induced hypertension

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...

Reexamination Certificate

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Reexamination Certificate

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07399596

ABSTRACT:
Provided are: a method for predicting the onset of pregnancy-induced hypertension (PIH) by precisely detecting abnormalities that occur before the onset of PIH (where such abnormalities have been impossible to detect by various conventional testing methods for PIH) while imposing less of a burden on a subject; a method for evaluating a fetus and placental functions in PIH; and a method for detecting PIH, which comprises measuring the level of human lipocalin-type prostaglandin D synthase (L-PGDS) in a body fluid sample collected from a subject.

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patent: 6790635 (2004-09-01), Seiki et al.
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patent: 0999447 (1998-05-01), None
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patent: 2001-215226 (2001-08-01), None
patent: 2004-220354 (2001-08-01), None
Manya et al, Comparative study of the asparagine-linked sugar chains of human lipocalin-type prostaglandin d syntase purified from urine and amniotic fluid, and recombinantly expressed in chinese hamster ovary cells, 2000, J Biochem, vol. 127, pp. 1001-1011.
Eguchi et al, Expression of lipocalin-type prostaglandin D synthase (B-trace) in human heart and its accumulation in the coronary circulation of angina patients, 1997, PNAS, vol. 94 14689-94.
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Oda et al, Development and evaluation of a practical ELISA for human urinary lipocalin-type prostaglandin D synthase.
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Edelstam et al, New reference values for routine blood samples and human neutrophilic lipocalin during thrid-trimester pregnancy, 200, Scand J Clin Lab Invest, vol 61, pp. 583-591.
Shiki et al.: “Changes of lipocalin-type prostaglandin D synthase level during pregnancy”. J. Obstet. Gynaecol. Res., vol. 30, No. 1, pp. 65-70 (Feb. 2004).
Melegos et al.: “Prostaglandin D2 synthase: a component of human amniotic fluid and its association with fetal abnormalities”. Clinical Chemistry, vol. 42, No. 7, pp. 1042-1050 (1996).
Shiki et al.: “Changes of lipocalin-type prostaglandin D synthase level during pregnancy”. J. Obstet. Gynaecol. Res., vol. 30, No. 1, pp. 65-70 (Feb. 2004).
Melegos et al.: “Prostaglandin D2 synthase: a component of human amniotic fluid and its association with fetal abnormalities”. Clinical Chemistry, vol. 42, No. 7, pp. 1042-1050 (1996).
English Language Abstract of JP2001-220354.
English Language Abstract of JP2001-215226.

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