Method for performing submicroliter crystallization experiments

Chemistry: physical processes – Physical processes – Crystallization

Reexamination Certificate

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C117S014000, C436S086000, C436S174000

Reexamination Certificate

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06932845

ABSTRACT:
A method is provided for performing crystallization experiments for a molecule, the method comprising performing a plurality of crystallization experiments where the crystallization experiments have volumes of less than 1 microliter, the crystallization experiments comprising a molecule to be crystallized and a composition that varies among the plurality of crystallization experiments detecting crystal formation in the crystallization experiments.

REFERENCES:
patent: 4263010 (1981-04-01), Randolph
patent: 4668584 (1987-05-01), Uzgiris et al.
patent: 4755363 (1988-07-01), Fujita et al.
patent: 4833233 (1989-05-01), Carter
patent: 4886646 (1989-12-01), Carter et al.
patent: 4900147 (1990-02-01), Browley et al.
patent: 4909933 (1990-03-01), Carter et al.
patent: 4919899 (1990-04-01), Herrmann et al.
patent: 5009861 (1991-04-01), Plaas-Link
patent: 5013531 (1991-05-01), Snyder et al.
patent: 5076698 (1991-12-01), Smith et al.
patent: 5078975 (1992-01-01), Rhodes et al.
patent: 5096676 (1992-03-01), McPherson et al.
patent: 5106592 (1992-04-01), Stapelmann et al.
patent: 5124935 (1992-06-01), Wallner et al.
patent: 5193685 (1993-03-01), Trevithick
patent: 5221410 (1993-06-01), Kushner et al.
patent: 5256241 (1993-10-01), Noever
patent: 5419278 (1995-05-01), Carter
patent: 5544254 (1996-08-01), Hartley et al.
patent: 5581476 (1996-12-01), Osslund
patent: 5641681 (1997-06-01), Carter
patent: 5643540 (1997-07-01), Carter et al.
patent: 5790421 (1998-08-01), Osslund
patent: 5855753 (1999-01-01), Trau et al.
patent: 5872010 (1999-02-01), Karger et al.
patent: 5873394 (1999-02-01), Meltzer
patent: 5973779 (1999-10-01), Ansari et al.
patent: 5985356 (1999-11-01), Schultz et al.
patent: 5997636 (1999-12-01), Gamamik et al.
patent: 6036920 (2000-03-01), Pantoliano et al.
patent: 6039804 (2000-03-01), Kim et al.
patent: 6057159 (2000-05-01), Lepre
patent: 6069934 (2000-05-01), Verman et al.
patent: 6148878 (2000-11-01), Ganz et al.
patent: 6268158 (2001-07-01), Pantoliano et al.
patent: 6297021 (2001-10-01), Nienaber et al.
patent: 6303322 (2001-10-01), Pantoliano et al.
patent: 6360792 (2002-03-01), Ganz et al.
patent: 6402837 (2002-06-01), Shtrahman et al.
patent: 6404849 (2002-06-01), Olson et al.
patent: 6417007 (2002-07-01), Gittleman et al.
patent: 6558623 (2003-05-01), Ganz et al.
patent: 6579358 (2003-06-01), Delucas et al.
patent: 6592824 (2003-07-01), Delucas et al.
patent: 2001/0006807 (2001-07-01), Bray et al.
patent: 2001/0016191 (2001-08-01), Osslund
patent: 2001/0016314 (2001-08-01), Anderson et al.
patent: 2001/0019845 (2001-09-01), Bienert et al.
patent: 2001/0027745 (2001-10-01), Weigl et al.
patent: 2001/0032582 (2001-10-01), DeTitta et al.
patent: 2001/0055669 (2001-12-01), Schultz et al.
patent: 2001/0055775 (2001-12-01), Schultz et al.
patent: 2002/0022250 (2002-02-01), Hendrickson et al.
patent: 2002/0029814 (2002-03-01), Unger et al.
patent: 2002/0048610 (2002-04-01), Cima et al.
patent: 2002/0054663 (2002-05-01), Olson et al.
patent: 2002/0062783 (2002-05-01), Bray
patent: 2002/0064485 (2002-05-01), DeLucas et al.
patent: 2002/0067800 (2002-06-01), Newman et al.
patent: 2002/0106318 (2002-08-01), DeLucas et al.
patent: 2002/0110816 (2002-08-01), Santarsiero et al.
patent: 2002/0143153 (2002-10-01), Santarsiero et al.
patent: 2002/0144738 (2002-10-01), Unger et al.
patent: 2002/0155504 (2002-10-01), Santarsiero et al.
patent: 2002/0164812 (2002-11-01), DeLucas
patent: 2002/0169512 (2002-11-01), Stewart
patent: 2002/0173052 (2002-11-01), Santarsiero et al.
patent: 2002/0182637 (2002-12-01), Santarsiero et al.
patent: 2003/0000597 (2003-01-01), Ganz et al.
patent: 2003/0022383 (2003-01-01), DeLucas
patent: 2003/0022384 (2003-01-01), DeLucas
patent: 2003/0027348 (2003-02-01), DeLucas et al.
patent: 2003/0027997 (2003-02-01), Bray et al.
patent: 2003/0096421 (2003-05-01), DeLucas et al.
patent: 0 553 539 (1993-04-01), None
patent: 02001013054 (2001-01-01), None
patent: WO 99/04361 (1999-01-01), None
patent: WO 00/60345 (2000-12-01), None
patent: WO 01/92293 (2001-12-01), None
patent: WO 02/093139 (2002-11-01), None
patent: WO 01/26797 A2 (2003-04-01), None
Abola, Enrique et al., “Automation of X-ray crystallography”, Nature Structural Biology, Structural Genomics Supplement, (Nov. 2000), pp. 973-977.
Presentation: “PBD/Research/Research Areas/ AUTOMATION” (Feb. 28, 2002). http://www.lbl.gov/LBL-Programs/pbd/xl_research/automation.html 4 pages.
Chayen, Naomi E., “Tackling the bottleneck of protein crystallization in the post-gemonic era”, TRENDS in Biotechnology, vol. 20, No. 3 (Mar. 2002), 1 page.
Chayen, Naomi E., “The role of oil in macromolecular crystallization”, Structure, vol. 5, No. 10 (1997), pp. 1269-1274.
Chayen, Naomi E. et al., Apocruslacyanin A1 from the lobster carotenoprotein α-crustacyanin: crystallization and initial X-ray analysis involving softer X-rays, Acta Cryst. D56 (2000), pp. 1064-1066.
Chayen, N.E. et al., “Porous Silicon: an Effective Nucleation-inducing Material for Protein Crystallization”, J. Mol. Biol., Academic Press, 312 (2001), pp. 591-595.
Chayen, Naomi E. et al., “Protein crystallization for genomics: towards high-throughput optimization techniques”, Acta Cryst. D58 (2002), pp. 921-927.
Chayen, N.E. et al., “Trends and Challenges in Experimental Macromolecular Crystallography”, Quarterly Review of Biophysics 29, 3 (1996), pp. 227-278.
Chayen, Naomi E. et al., “Purification, crystaliation and initial X-ray analysis of the C1subunit of the astaxanthin protein, V600, of the chondrophoreVelella velella”, Acta Cryst. D55, (1999), pp. 266-268.
Chayen, Naomi E. et al., “Space-grown crystals may prove their worth”, Nature 398, 20 (1999), p. 6722.
Cianci, M. et al., “Structure of lobster apocrystacyanin A1using softer X-rays”, Acta Cryst. D57 (2001), pp. 1219-1229.
Press Release: “Crystallomics Core”, Crystallomics Core at JCSG, http://bioinfo-core.jcsg.org/bic/links/crystallomics.htm (Apr. 18, 2001), 2 pages.
Delucas, Lawrence J. et al., “New High-throughput Crystallization Technology”, http://www.hwi.buffalo.edu/ACA/ACA02/abstracts/text/E0014.html (2002), 1 page.
Dong, Jun et al., “Bound-solvent structures for microgravity-, ground control-, gel- and microbatch-grown hen egg-white lysozyme crystals at 1.8Å resolution”, Acta Cryst., D55 (1999), pp. 745-752.
Douglas Instruments Proposal: Large-scale Xn “The use of Microbatch for Large Scale Crystallization Projects”, http://douglas.co.uk/proposal.htm (Feb. 22, 2001), 6 pages.
Douglas Instruments Website: Differences—The Major Differences between Oryx 6 and IMPAX 1-5 (Mar. 2001), 1 page.
Douglas Instruments Website: “Harvesting—Harvesting Crystals from Microbatch for Cryocrystallography”, Research Report 3 (Oct. 1995), 4 pages.
Douglas Instruments, Impax—IMPAX 1-5 for Crystallization with Microbatch, www.douglas.co.uk.impax.htm (printed on Feb. 19, 2004), 8 pages.
Douglas Instruments Website: “Oryx 6 for Crystallization with Microbatch and Sitting Drop”, http://douglas.co.uk/oryx.htm (printed on Feb. 19, 2004), 7 pages.
Eickhoff, Holger et al. Webpage: “An Automated Platform for Miniaturized Protein Crystallization” (2002), Greiner Bio-One (Abstract), 1 page.
Erlandsen, Heidi et al. “Combining structural genomics and enzymology: completing the picture in metabolic pathways and enzyme active sites” (2000), Current Opinion Structural Biology, 10, pp. 719-730.
Fiehn, Hendrik et al., “Microsystem Technology for Pipetting Systems: Parallel Sample Treatment in the Submicroliter Range (25)”, Small Talk the microfluidics and microarrays Conference Final Conference Program, Association for Laboratory Automation, (Jul. 6-Dec. 2000), San Diego, California (Abstract), 2 pages.
Gaasterland, Terry, “Feasibility of Structural Genomics and Impact on Computational Biology: Post-Workshop Review”, Mathemat

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