Drug – bio-affecting and body treating compositions – In vivo diagnosis or in vivo testing – Magnetic imaging agent
Reexamination Certificate
2007-03-23
2010-06-29
Saoud, Christine J (Department: 1647)
Drug, bio-affecting and body treating compositions
In vivo diagnosis or in vivo testing
Magnetic imaging agent
C424S009100, C424S649000, C514S561000, C514S034000, C514S269000, C514S283000, C514S492000, C514S449000, C435S040000
Reexamination Certificate
active
07744854
ABSTRACT:
This invention provides a method for a method for optimizing the regimen for the administration of chemotherapeutic agents. The method comprises administration of a selenium compound to an individual, monitoring the modulation of tumor vessel maturation (TVM) to identify an optimal time for administration of a chemotherapeutic agent. This invention also provides a method to determine whether or not a tumor is likely to be a responder to chemotherapy. The method comprises administration of a selenium compound to an individual and determining whether or not an increase in TVM is observed. An increased TVM following administration of selenium is an indication that the tumor will likely respond the chemotherapy.
REFERENCES:
Bhattacharya et al. Proc. Am. Assoc. Canc. Res. Ann. Mtng. (Apr. 2006) vol. 47, 413-414.
Cao et al. Clin. Canc. Res. 10: 2561-2569, 2004.
Fakih, M.G. et al, A Phase I and Pharmacokinetic Study of Fixed-Dose Selenomethionine and Irinotecan in Solid Tumors, Clinical Cancer Research, Feb. 15, 2006, 1237-1244, vol. 12(4).
Azrak Rami G.
Bhattacharya Arup
Chintala Sreenivasulu
Mazurchuk Richard
Rustum Youcef M.
Health Research , Inc.
Hodgson & Russ LLP
Saoud Christine J
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