Method for optimizing cancer therapy by monitoring...

Drug – bio-affecting and body treating compositions – In vivo diagnosis or in vivo testing – Magnetic imaging agent

Reexamination Certificate

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C424S009100, C424S649000, C514S561000, C514S034000, C514S269000, C514S283000, C514S492000, C514S449000, C435S040000

Reexamination Certificate

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07744854

ABSTRACT:
This invention provides a method for a method for optimizing the regimen for the administration of chemotherapeutic agents. The method comprises administration of a selenium compound to an individual, monitoring the modulation of tumor vessel maturation (TVM) to identify an optimal time for administration of a chemotherapeutic agent. This invention also provides a method to determine whether or not a tumor is likely to be a responder to chemotherapy. The method comprises administration of a selenium compound to an individual and determining whether or not an increase in TVM is observed. An increased TVM following administration of selenium is an indication that the tumor will likely respond the chemotherapy.

REFERENCES:
Bhattacharya et al. Proc. Am. Assoc. Canc. Res. Ann. Mtng. (Apr. 2006) vol. 47, 413-414.
Cao et al. Clin. Canc. Res. 10: 2561-2569, 2004.
Fakih, M.G. et al, A Phase I and Pharmacokinetic Study of Fixed-Dose Selenomethionine and Irinotecan in Solid Tumors, Clinical Cancer Research, Feb. 15, 2006, 1237-1244, vol. 12(4).

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