Method for obtaining antifungal and herbicidal compounds that ta

Details Method for obtaining antifungal and herbicidal compounds that ta Method for obtaining antifungal and herbicidal compounds that ta

1994-12-28

1996-12-10

Wax, Robert A.

Chemistry: molecular biology and microbiology

Spore forming or isolating process

4352523, 43525411, 4353201, 4351723, 435193, 536 232, C12N 115, C12N 119, C12N 121, C12N 510, C12N 1554, C12N 1563

Patent

active

055830307

ABSTRACT:
The invention provides the LCB1 and LCB2 genes of the yeast Saccharomyces cerevisiae that encode subunits of the enzyme serine palmitoyltransferase (SPT), the first enzyme leading to synthesis of the long-base component of the sphingolipids. The present specification describes the isolation of the LCB1 and LCB2 genes. The invention further relates to methods of using these genes to either inhibit SPT activity or to inhibit synthesis of the enzyme. Furthermore, the invention relates to methods for constructing strains of S. cerevisiae or other organisms that can be used to select and to test for compounds that either inhibit SPT activity or to inhibit synthesis of the enzyme.

REFERENCES:
Nagiec et al., (1994) Proc. Nat. Acad. Sci., USA 91:.
Pinto et al., (1986) Federation Proceedings 45: 1826.
Wells et al., (1983) J. Biological Chemistry 258: 10200-10203.

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