Method for measuring 3-deoxyglucosone derivatives in a sample

Details Method for measuring 3-deoxyglucosone derivatives in a sample Method for measuring 3-deoxyglucosone derivatives in a sample

1995-03-20

1997-04-08

Soderquist, Arlen

Chemistry: analytical and immunological testing

Nuclear magnetic resonance, electron spin resonance or other...

436 8, 436 14, 436 56, 436 94, 436 95, 436128, 436161, 436174, 436177, 436 57, G01N 3006, G01N 3014, G01N 3072

Patent

active

056187343

ABSTRACT:
For determining 3-deoxyglucosone derivatives which are intermediate metabolites of the Maillard reaction in body fluids such as blood, urine, serum, plasma and the like in gas chromatography/mass spectrometry, .sup.13 C-labelled compounds or .sup.14 C-labelled compounds are useful as an internal standard substance. More specifically, 3-deoxyglucosone derivatives having the formula (I): ##STR1## wherein *C is .sup.13 C or .sup.14 C, X is O or N--OR wherein R is Me, Et or H, and Y is SiMe.sub.3 or SiMe.sub.2 tBu, and their production are provided. The measurement of 3-deoxyglucosone derivatives is useful in diagnosing diseases such as diabetes and diseases complicated with diabetes, including diabetic nephrosis, various renal disorders, renal insufficiency, metabolic diseases of carbohydrate and the like.

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