Method for measurement of serotonin uptake sites and radioligand

Details Method for measurement of serotonin uptake sites and radioligand Method for measurement of serotonin uptake sites and radioligand

1990-12-26

1992-06-09

Maples, John B.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

436 57, 436501, 544363, G01N 2300, C07D40100, C12Q 100

Patent

active

051206412

ABSTRACT:
Disclosed herein is an improved method for measurement of serotonin uptake sites in a sample, in which a radioligand is incubated with a sample and then the radioactivity of the radioligand bound to the sample is determined, wherein the improvement comprises using tritium-labeled 6-nitro-2-N-piperazinylquinoline or an acid addition salt thereof as the radioligand.

REFERENCES:
Radioisotopes, vol. 39, No. 4, pp. 168-169.
Eur. J. Pharmacol., 180 (1990) 273-281.
J. Pharmacol. Exp. Ther., 225, No. 1, 146-153.
Eur. J. Pharmacol., 187 (1990) 295-302.
Fundam. Clin. Pharmacol., (1990), 4, 635-641.
Hashimoto, K. et al., "Preparation of [3H]-6-Nitroquipazine . . . Inhibitor", Radioisotopes, 39(4), 168-9, 1990 [CA. 114(1): 6442q] (Abstract).

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