Method for inhibiting production of IgE by using IL-9 inhibitors

Details Method for inhibiting production of IgE by using IL-9 inhibitors Method for inhibiting production of IgE by using IL-9 inhibitors

1991-12-13

1993-09-21

Wax, Robert A.

Drug, bio-affecting and body treating compositions

Lymphokine

424 852, 514 8, 514 21, 53038822, 53038823, A61K 4505, A61K 3900, A61K 3710, A61K 3700

Patent

active

052467015

ABSTRACT:
A method for inhibiting production of IgE, and a method for enhancing production of IgG are taught. The methods are linked to the role of interleukin 9 in antibody production. Specifically, production of IgG is potentiated by administering either to a subject or a cell culture a combination of interleukin 4 and interleukin 9. Production of IgE is inhibited by administering an amount of an interleukin 9 inhibitor to a subject.

REFERENCES:
patent: 4578335 (1986-03-01), Urdal et al.
patent: 5116951 (1992-05-01), Druez et al.
Mosley et al. (1989) Cell 59:335-348.
Hultner et al. (1990) Eur. J. Immunol. 20(6):1413-1416.
Dugas et al. (1990) Lymphokine Res. 9(4):572.
Druez et al. (Oct. 15, 1990) J. Immunol. 145(8):2494-2499.
Knight, "Allergy: Big Market, Big Risks": Bio/Technology 8: 717-719 (1990).
Fernandez-Botran et al., Proc. Natl. Acad. Sci. 87: 4202-4206 (Jun. 1990).
Sadick et al., J. Exp. Med. 171: 115-127 (Jan. 1990).
Henzel et al., J. Exp. Med. 169: 59-72 (Jan. 1989).
Coffman et al., Science 245: 08-310 (Jul. 21, 1989).
Aggarwal et al., Clinical Research (Blackwell), 1992, p. 113.

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