Method for increasing the vitamin B.sub.12 production in ferment

Details Method for increasing the vitamin B.sub.12 production in ferment Method for increasing the vitamin B.sub.12 production in ferment

1974-10-24

1976-06-22

Tanenholtz, Alvin E.

Textiles: fiber preparation

195115, C12D 506

Patent

active

039649717

ABSTRACT:
The invention relates to a method for increasing the vitamin B.sub.12 production of fermentation processes performed in a known way with a mixed population of mesophilic methane-producing bacteria under anaerobic conditions. According to the invention in an enrichment period of preferably 4 to 7 days a nutrient concentrate containing mainly inorganic ammonium compounds as nitrogen source and mainly methanol as carbon source and having a N:C weight ratio of 1:10 to 1:20, preferably 1:11 to 1:15 is added in daily portions to a fermentation broth obtained from a usual vitamin B.sub.12 fermentation process and containing living bacterium populations so as to increase the total concentration of assimilable nitrogen by a factor of maximum 4 until the end of the enrichment period, and thereafter the fermentation is terminated and the obtained fermentation broth with an increased vitamin B.sub.12 content is processed, or the fermentation is continued by periodically removing a portion of the fermentation broth and supplementing it with a same volume of fresh nutrient medium containing mainly inorganic ammonium compounds as nitrogen source and mainly methanol as carbon source and having a N:C weight ratio of 1:10 to 1:20, preferably 1:11 to 1:15.
By this process fermentation broths with as high vitamin B.sub.12 concentration as 40.000 mcg./l. can be obtained.

REFERENCES:
patent: 3062724 (1962-11-01), Reusser

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