Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1995-06-06
1998-05-05
Tsang, Cecilia J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
514 13, 514 14, 514 21, 604 20, 530324, 530325, 530326, 530327, A61K 3800, A61K 3804, A01N 130, C07K 700
Patent
active
057474532
ABSTRACT:
Methods for modifying polypeptide agents to enhance their transdermal electrotransport flux are provided. The polypeptide is modified by reducing the potential of the polypeptide for forming .alpha.-helical or .beta.-sheet segments. In particular, amino acid residues known to stabilize .alpha.-helical and .beta.-sheet segments can be replaced with destabilizing residues and known helix breakers. Modified molecules and compositions including the molecules are also provided.
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Holladay Leslie A.
Oldenburg Kevin R.
ALZA Corporation
Harle Jennifer
Miller D. Byron
Rogers Christopher P.
Stone Steven F.
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