Method for increasing the electrotransport flux of polypeptides

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai

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514 13, 514 14, 514 21, 604 20, 530324, 530325, 530326, 530327, A61K 3800, A61K 3804, A01N 130, C07K 700

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057474532

ABSTRACT:
Methods for modifying polypeptide agents to enhance their transdermal electrotransport flux are provided. The polypeptide is modified by reducing the potential of the polypeptide for forming .alpha.-helical or .beta.-sheet segments. In particular, amino acid residues known to stabilize .alpha.-helical and .beta.-sheet segments can be replaced with destabilizing residues and known helix breakers. Modified molecules and compositions including the molecules are also provided.

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