Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Patent
1996-11-12
2000-01-11
Scheiner, Laurie
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
435 5, 435 911, 435 913, 4352872, C12Q 168
Patent
active
060134372
ABSTRACT:
A method for identifying translationally regulated genes includes selectively stimulating translation of an unknown target mRNA with a stress inducing element wherein the target mRNA is part of a larger sample of mRNA. The mRNA sample is divided into pools of translated and untranslated mRNA which are differentially analyzed to identify genes that are translationally regulated by the stress inducing element. A method for identifying gene sequences coding for internal ribosome entry sites includes inhibiting 5' cap-dependant mRNA translation in a cell, collecting a pool of mRNA from the cells, and differentially analyzing the pool of mRNA to identify genes with sequences coding for internal ribosome entry sites.
REFERENCES:
patent: 5459037 (1995-10-01), Sutcliffe et al.
patent: 5525471 (1996-06-01), Zeng
Einat Paz
Grosman Zehava
Harris Nicholas
Luria Sylvie
Skaliter Rami
QBI Enterprises, Ltd.
Scheiner Laurie
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