Purification process of a human growth hormone

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Hormones – e.g. – prolactin – thymosin – growth factors – etc.

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Details

435 694, 530306, B01D 1508, C07D25154, C12N 1570, C12P 2102

Patent

active

057601879

ABSTRACT:
A human growth hormone can be purified by allowing a solution containing the human growth hormone to contact with a blue pigment-bonded carrier in order to selectively adsorb the human growth hormone, then eluting the human growth hormone with an eluant of high ionic strength or an eluant containing a protein denaturing agent. This method readily enables the mass production of a highly purified human growth hormone.

REFERENCES:
patent: 4332717 (1982-06-01), Kanaoka et al.
patent: 4342832 (1982-08-01), Goeddel et al.
patent: 5496713 (1996-03-01), Honjo et al.

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