Method for discriminating platelets from red blood cells

Details Method for discriminating platelets from red blood cells Method for discriminating platelets from red blood cells

2005-11-09

2008-03-18

Wallenhorst, Maureen M. (Department: 1797)

Chemistry: analytical and immunological testing

Biological cellular material tested

C436S008000, C436S010000, C436S017000, C436S164000, C436S174000, C436S175000, C422S073000, C422S082050, C422S082090, C435S002000

Reexamination Certificate

active

07344890

ABSTRACT:
A method for discriminating and quantifying platelets within an analyzed blood sample involves initially diluting the blood sample with a ghosting reagent that causes a change in the index of refraction of the red blood cells. Owing to the change in the index of refraction, light scattered from the ghosted red blood cells will be substantially reduced relative to light scattered from platelets. This results in locations of platelets within a scatterplot of the analyzed blood sample to fall within a region distinguishable from those containing normal red blood cells, fragmented red blood cells, and microcytic red blood cells.

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