Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Patent
1996-06-25
1998-01-06
Marschel, Ardin H.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
435810, 436501, 536 231, 536 241, 536 243, 536 2431, 536 2432, 536 2433, 935 77, 935 78, C12Q 168
Patent
active
057053464
ABSTRACT:
A method for detecting a target nucleic acid comprises the steps of reacting a sample with a probe in the presence of two or more kinds of reagents capable of being made an irreversible change capable of being detected and accumulating by an interaction through a double helix structure under a condition enabling the replication of the formation and dissociation of a hybrid composed of the target nucleic acid in the sample and the probe, accumulating the irreversible change caused by the interaction of the reagents, and then detecting the accumulated change.
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Comprehensive Dictionary of Physical Chemistry, L. Ulicky and T. J. Kemp ed. Ellis Horwood Publisher p. 103.
Purugganan, et al. Accelerated Electron Transfer Between Metal Complexes Mediated by DNA. Science (23. Sep. 1988) 241:1645-1649.
Rahman., et al. Complexes involving quercetin, DNA and Cu(II), Carcinognesis (1990) 11:2001-2003.
Strobel et al. Preparation and Characterization of Spin-Labeled Oligonucleotides for DNA Hybridization, Bioconj. Chem (1991) 2:89-95.
Cullis et al. Electorn Conduction and Trapping in DNA: An Electron Spin Resonance Study. J. Chem. Soc. Faraday Trans. (1990) 86:591-592.
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Kawaguchi Masahiro
Makino Keisuke
Murakami Akira
Okamoto Tadashi
Tomida Yoshinori
Canon Kabushiki Kaisha
Marschel Ardin H.
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