Method for decreasing tumor metastasis

Details Method for decreasing tumor metastasis Method for decreasing tumor metastasis

1987-06-24

1989-11-21

Stone, Jacqueline M.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

536 21, A61K 31725, C08B 3710

Patent

active

048823180

ABSTRACT:
The invention relates to pharmaceutical compositions intended to decrease the incidence of tumor metastasis in patients who suffer from malignant diseases.
The pharmaceutical compositions of the invention contain as active ingredient heparin or a suitable derivative thereof. Amongst suitable derivatives are N-desulfated and N-acetylated heparin.
The dosage of the administered heparin or heparin derivative is quite critical and will generally be in the range of from 0.05 mg/kg/day to about 0.5 mg/kg/day. A preferred range is between about 0.1 mg/kg/day to about 0.5 mg/kg/day.

REFERENCES:
patent: 3033750 (1962-05-01), Velluz et al.
patent: 4575056 (1988-07-01), Van Gorp et al.
Folkman et al, Science, vol. 221, 19 Aug. 1983, pp. 719-725.

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